Difference between revisions of "RecQ"

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(Reviews)
(Extended information on the protein)
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* '''Effectors of protein activity:'''
 
* '''Effectors of protein activity:'''
  
* '''Interactions:'''
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* '''[[SubtInteract|Interactions]]:'''
  
* '''Localization:''' cell membrane (according to Swiss-Prot)
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* '''[[Localization]]:''' cell membrane (according to Swiss-Prot)
  
 
=== Database entries ===
 
=== Database entries ===

Revision as of 18:38, 9 December 2011

  • Description: ATP-dependent DNA helicase

Gene name recQ
Synonyms recS, ypbC
Essential no
Product ATP-dependent DNA helicase
Function replication reactivation pathway
MW, pI 56 kDa, 6.228
Gene length, protein length 1488 bp, 496 aa
Immediate neighbours ypbD, ypbB
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
RecQ context.gif
This image was kindly provided by SubtiList



Categories containing this gene/protein

DNA repair/ recombination, membrane proteins

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU23020

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: RecQ subfamily (according to Swiss-Prot)
  • Paralogous protein(s): YocI

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Kara A Bernstein, Serge Gangloff, Rodney Rothstein
The RecQ DNA helicases in DNA repair.
Annu Rev Genet: 2010, 44;393-417
[PubMed:21047263] [WorldCat.org] [DOI] (I p)

Leonard Wu, Ian D Hickson
RecQ helicases and cellular responses to DNA damage.
Mutat Res: 2002, 509(1-2);35-47
[PubMed:12427530] [WorldCat.org] [DOI] (P p)


Original Publications

François Lecointe, Céline Sérèna, Marion Velten, Audrey Costes, Stephen McGovern, Jean-Christophe Meile, Jeffrey Errington, S Dusko Ehrlich, Philippe Noirot, Patrice Polard
Anticipating chromosomal replication fork arrest: SSB targets repair DNA helicases to active forks.
EMBO J: 2007, 26(19);4239-51
[PubMed:17853894] [WorldCat.org] [DOI] (P p)