RecQ

• Description: ATP-dependent DNA helicase
  
  

Gene name	recQ
Synonyms	recS, ypbC
Essential	no
Product	ATP-dependent DNA helicase
Function	replication reactivation pathway
Gene expression levels in SubtiExpress: recQ
MW, pI	56 kDa, 6.228
Gene length, protein length	1488 bp, 496 aa
Immediate neighbours	ypbD, ypbB
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

DNA repair/ recombination, membrane proteins

The gene

Basic information

• Locus tag: BSU23020

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: RecQ subfamily (according to Swiss-Prot)

• Paralogous protein(s): YocI

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cell membrane (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: P50729

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Expression browser: recQ PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:
  • 1A893 (no resistance), PubMed, available at BGSC

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

Kara A Bernstein, Serge Gangloff, Rodney Rothstein
The RecQ DNA helicases in DNA repair.
Annu Rev Genet: 2010, 44;393-417
[PubMed:21047263] [WorldCat.org] [DOI] (I p)

Leonard Wu, Ian D Hickson
RecQ helicases and cellular responses to DNA damage.
Mutat Res: 2002, 509(1-2);35-47
[PubMed:12427530] [WorldCat.org] [DOI] (P p)

Original Publications

François Lecointe, Céline Sérèna, Marion Velten, Audrey Costes, Stephen McGovern, Jean-Christophe Meile, Jeffrey Errington, S Dusko Ehrlich, Philippe Noirot, Patrice Polard
Anticipating chromosomal replication fork arrest: SSB targets repair DNA helicases to active forks.
EMBO J: 2007, 26(19);4239-51
[PubMed:17853894] [WorldCat.org] [DOI] (P p)