RecG

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  • Description: ATP-dependent DNA helicase, branch migration translocase, required for DNA repair and chromosomal segregation

Gene name recG
Synonyms ylpB
Essential no
Product ATP-dependent DNA helicase, branch migration translocase
Function DNA repair and chromosomal segregation
Metabolic function and regulation of this protein in SubtiPathways:
Ala, Gly, Ser
MW, pI 77 kDa, 7.093
Gene length, protein length 2046 bp, 682 aa
Immediate neighbours sdaAA, fapR
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
RecG context.gif
This image was kindly provided by SubtiList







The gene

Basic information

  • Locus tag: BSU15870

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: helicase C-terminal domain (according to Swiss-Prot)
  • Paralogous protein(s): Mfd

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • Structure: 1GM5 (from Thermotoga maritima, 43% identity, 62% similarity)
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

François Lecointe, Céline Sérèna, Marion Velten, Audrey Costes, Stephen McGovern, Jean-Christophe Meile, Jeffrey Errington, S Dusko Ehrlich, Philippe Noirot, Patrice Polard
Anticipating chromosomal replication fork arrest: SSB targets repair DNA helicases to active forks.
EMBO J: 2007, 26(19);4239-51
[PubMed:17853894] [WorldCat.org] [DOI] (P p)

Humberto Sanchez, Begoña Carrasco, M Castillo Cozar, Juan C Alonso
Bacillus subtilis RecG branch migration translocase is required for DNA repair and chromosomal segregation.
Mol Microbiol: 2007, 65(4);920-35
[PubMed:17640277] [WorldCat.org] [DOI] (P p)

Qin Wen, Akeel A Mahdi, Geoffrey S Briggs, Gary J Sharples, Robert G Lloyd
Conservation of RecG activity from pathogens to hyperthermophiles.
DNA Repair (Amst): 2005, 4(1);23-31
[PubMed:15533834] [WorldCat.org] [DOI] (P p)