RecG

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  • Description: ATP-dependent DNA helicase, branch migration translocase, required for DNA repair and chromosomal segregation

Gene name recG
Synonyms ylpB
Essential no
Product ATP-dependent DNA helicase, branch migration translocase
Function DNA repair and chromosomal segregation
Gene expression levels in SubtiExpress: recG
Interactions involving this protein in SubtInteract: RecG
Metabolic function and regulation of this protein in SubtiPathways:
recG
MW, pI 77 kDa, 7.093
Gene length, protein length 2046 bp, 682 aa
Immediate neighbours sdaAA, fapR
Sequences Protein DNA DNA_with_flanks
Genetic context
RecG context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
RecG expression.png




























Categories containing this gene/protein

DNA repair/ recombination

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU15870

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: helicase C-terminal domain (according to Swiss-Prot)
  • Paralogous protein(s): Mfd

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 1GM5 (from Thermotoga maritima, 43% identity, 62% similarity)
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

François Lecointe, Céline Sérèna, Marion Velten, Audrey Costes, Stephen McGovern, Jean-Christophe Meile, Jeffrey Errington, S Dusko Ehrlich, Philippe Noirot, Patrice Polard
Anticipating chromosomal replication fork arrest: SSB targets repair DNA helicases to active forks.
EMBO J: 2007, 26(19);4239-51
[PubMed:17853894] [WorldCat.org] [DOI] (P p)

Humberto Sanchez, Begoña Carrasco, M Castillo Cozar, Juan C Alonso
Bacillus subtilis RecG branch migration translocase is required for DNA repair and chromosomal segregation.
Mol Microbiol: 2007, 65(4);920-35
[PubMed:17640277] [WorldCat.org] [DOI] (P p)

Qin Wen, Akeel A Mahdi, Geoffrey S Briggs, Gary J Sharples, Robert G Lloyd
Conservation of RecG activity from pathogens to hyperthermophiles.
DNA Repair (Amst): 2005, 4(1);23-31
[PubMed:15533834] [WorldCat.org] [DOI] (P p)

Additional publications: PubMed