Difference between revisions of "RecD2"

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(→‎Extended information on the protein)
 
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* '''Description:''' similar to exodeoxyribonuclease V alpha subunit <br/><br/>
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* '''Description:''' 5'-3' DNA helicase replication fork progression <br/><br/>
  
 
{| align="right" border="1" cellpadding="2"  
 
{| align="right" border="1" cellpadding="2"  
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|style="background:#ABCDEF;" align="center"| '''Essential''' || no  
 
|style="background:#ABCDEF;" align="center"| '''Essential''' || no  
 
|-
 
|-
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|style="background:#ABCDEF;" align="center"| '''Product''' || unknown
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|style="background:#ABCDEF;" align="center"| '''Product''' || 5'-3' DNA helicase
 
|-
 
|-
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|style="background:#ABCDEF;" align="center"|'''Function''' || unknown
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|style="background:#ABCDEF;" align="center"|'''Function''' || replication fork progression
 
|-
 
|-
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://cellpublisher.gobics.de/subtinteract/startpage/start/ ''Subt''Interact]''': [http://cellpublisher.gobics.de/subtinteract/interactionList/2/YrrC YrrC]
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU27480 RecD2]
 +
|-
 +
|colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://subtiwiki.uni-goettingen.de/interact/ ''Subt''Interact]''': [http://subtiwiki.uni-goettingen.de/interact/index.php?protein=RecD2 RecD2]
 
|-
 
|-
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 88 kDa, 5.08   
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 88 kDa, 5.08   
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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[yrrD]]'', ''[[yrrB]]''
 
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[yrrD]]'', ''[[yrrB]]''
 
|-
 
|-
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|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+&#91;EMBLCDS:CAB14689&#93;+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
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|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU27480 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU27480 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU27480 DNA_with_flanks]
 
|-
 
|-
 
|colspan="2" | '''Genetic context''' <br/> [[Image:yrrC_context.gif]]
 
|colspan="2" | '''Genetic context''' <br/> [[Image:yrrC_context.gif]]
 
  <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
 
  <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
 +
|-
 +
|colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=yrrC_2806286_2808682_-1 Expression at a glance]'''&#160;&#160;&#160;{{PubMed|22383849}}<br/>[[Image:yrrC_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU27480]]
 
|-
 
|-
 
|}
 
|}
  
 
__TOC__
 
__TOC__
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+
<br/><br/><br/><br/>
 +
<br/><br/><br/><br/>
 +
<br/><br/><br/><br/>
 
<br/><br/>
 
<br/><br/>
  
 
= [[Categories]] containing this gene/protein =
 
= [[Categories]] containing this gene/protein =
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{{SubtiWiki category|[[genetics/ other]]}}
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{{SubtiWiki category|[[DNA replication]]}}
  
 
= This gene is a member of the following [[regulons]] =
 
= This gene is a member of the following [[regulons]] =
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* '''Locus tag:''' BSU27480
 
* '''Locus tag:''' BSU27480
−
 
−
[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=yrrC_2806286_2808682_-1 Expression]
 
  
 
===Phenotypes of a mutant ===
 
===Phenotypes of a mutant ===
 +
* modest increase in spontaneous mutation rate {{PubMed|24443534}}
  
 
=== Database entries ===
 
=== Database entries ===
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* '''Kinetic information:'''
 
* '''Kinetic information:'''
  
−
* '''Domains:'''  
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* '''[[Domains]]:'''  
  
 
* '''Modification:'''
 
* '''Modification:'''
  
−
* '''Cofactor(s):'''
+
* '''[[Cofactors]]:'''
  
 
* '''Effectors of protein activity:'''
 
* '''Effectors of protein activity:'''
  
 
* '''[[SubtInteract|Interactions]]:'''
 
* '''[[SubtInteract|Interactions]]:'''
−
** [[SsbA]]-[[YrrC]] {{PubMed|21170359}}
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** [[SsbA]]-[[RecD2]] {{PubMed|24443534,21170359}}
  
 
* '''[[Localization]]:'''
 
* '''[[Localization]]:'''
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* '''Operon:'''  
 
* '''Operon:'''  
 +
 +
* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=yrrC_2806286_2808682_-1 recD2] {{PubMed|22383849}}
  
 
* '''[[Sigma factor]]:'''  
 
* '''[[Sigma factor]]:'''  
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* '''Regulatory mechanism:'''  
 
* '''Regulatory mechanism:'''  
  
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* '''Additional information:'''  
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* '''Additional information:'''
  
 
=Biological materials =
 
=Biological materials =
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=References=
 
=References=
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'''Additional publications:''' {{PubMed|21170359}}
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<pubmed> 21170359 24443534 </pubmed>
 +
 
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Latest revision as of 17:51, 22 January 2014

  • Description: 5'-3' DNA helicase replication fork progression

Gene name yrrC
Synonyms
Essential no
Product 5'-3' DNA helicase
Function replication fork progression
Gene expression levels in SubtiExpress: RecD2
Interactions involving this protein in SubtInteract: RecD2
MW, pI 88 kDa, 5.08
Gene length, protein length 2394 bp, 798 aa
Immediate neighbours yrrD, yrrB
Sequences Protein DNA DNA_with_flanks
Genetic context
YrrC context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
YrrC expression.png















Categories containing this gene/protein

DNA replication

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU27480

Phenotypes of a mutant

  • modest increase in spontaneous mutation rate PubMed

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Modification:
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Brian W Walsh, Samantha A Bolz, Sarah R Wessel, Jeremy W Schroeder, James L Keck, Lyle A Simmons
RecD2 helicase limits replication fork stress in Bacillus subtilis.
J Bacteriol: 2014, 196(7);1359-68
[PubMed:24443534] [WorldCat.org] [DOI] (I p)

Audrey Costes, François Lecointe, Stephen McGovern, Sophie Quevillon-Cheruel, Patrice Polard
The C-terminal domain of the bacterial SSB protein acts as a DNA maintenance hub at active chromosome replication forks.
PLoS Genet: 2010, 6(12);e1001238
[PubMed:21170359] [WorldCat.org] [DOI] (I e)

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