Difference between revisions of "RatA"

From SubtiWiki
Jump to: navigation, search
 
(10 intermediate revisions by 3 users not shown)
Line 16: Line 16:
 
|style="background:#ABCDEF;" align="center"| '''Gene length''' || 222 bp
 
|style="background:#ABCDEF;" align="center"| '''Gene length''' || 222 bp
 
|-
 
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[yqbN]]'', ''[[bsrH]]''
+
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[txpA]]'', ''[[bsrH]]''
 
|-
 
|-
 
|style="background:#FAF8CC;" align="center"|'''[http://subtiwiki.uni-goettingen.de/genE_nucleotide.txt    Gene sequence      (+200bp)  ]'''  
 
|style="background:#FAF8CC;" align="center"|'''[http://subtiwiki.uni-goettingen.de/genE_nucleotide.txt    Gene sequence      (+200bp)  ]'''  
 
|-
 
|-
 
|colspan="2" | '''Genetic context''' <br/> [[Image:genE_context.gif]]
 
|colspan="2" | '''Genetic context''' <br/> [[Image:genE_context.gif]]
 +
|-
 +
|colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=S976_2678362_2678577_-1 Expression at a glance]'''&#160;&#160;&#160;{{PubMed|22383849}}<br/>[[Image:ratA_expression.png|500px]]
 
|-
 
|-
 
|}
 
|}
Line 30: Line 32:
 
= [[Categories]] containing this gene/protein =
 
= [[Categories]] containing this gene/protein =
 
{{SubtiWiki category|[[toxins, antitoxins and immunity against toxins]]}},
 
{{SubtiWiki category|[[toxins, antitoxins and immunity against toxins]]}},
 +
{{SubtiWiki category|[[Skin element]]}},
 
{{SubtiWiki category|[[ncRNA]]}}
 
{{SubtiWiki category|[[ncRNA]]}}
  
Line 44: Line 47:
  
 
=== Database entries ===
 
=== Database entries ===
 +
* '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=?&redirect=T ?]
 +
* '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=?&redirect=T ?]
  
 
* '''DBTBS entry:''' no entry
 
* '''DBTBS entry:''' no entry
Line 67: Line 72:
 
* '''Regulatory mechanism:'''  
 
* '''Regulatory mechanism:'''  
  
* '''Additional information:'''  
+
* '''Additional information:'''
 +
** the ''[[txpA]]'' mRNA-''[[RatA]]'' RNA duplex is degraded by [[rnc|RNase III]] {{PubMed|23300471}}
  
 
=Biological materials =
 
=Biological materials =
Line 90: Line 96:
  
 
=References=
 
=References=
 +
==Reviews==
 +
<pubmed> 23300472 </pubmed>
  
<pubmed>16166525, </pubmed>
+
==Original publications==
 +
<pubmed>16166525, 23300471</pubmed>
  
 
[[Category:small RNA]]
 
[[Category:small RNA]]

Latest revision as of 12:06, 28 January 2017

  • Description: regulatory RNA, ncRNA, antisense for txpA

Gene name ratA
Synonyms
Essential no
Product txpA antisense RNA
Function control of txpA expression
Gene length 222 bp
Immediate neighbours txpA, bsrH
Gene sequence (+200bp)
Genetic context
File:GenE context.gif
Expression at a glance   PubMed
RatA expression.png



Categories containing this gene/protein

toxins, antitoxins and immunity against toxins, Skin element, ncRNA

This gene is a member of the following regulons

The ratA regulon: txpA

The gene

Basic information

  • Locus tag:

Phenotypes of a mutant

Database entries

  • BsubCyc: ?
  • BsubCyc: ?
  • DBTBS entry: no entry
  • SubtiList entry:
  • Structure:

Additional information

The RNA

binds the txpA mRNA and triggers its degradation PubMed

Expression and regulation

  • Operon:
  • Regulation:
  • Regulatory mechanism:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Richard Losick, Harvard University, Cambridge, USA Homepage

Your additional remarks

References

Reviews

Fabian M Commichau, Jörg Stülke
A mystery unraveled: essentiality of RNase III in Bacillus subtilis is caused by resident prophages.
PLoS Genet: 2012, 8(12);e1003199
[PubMed:23300472] [WorldCat.org] [DOI] (I p)


Original publications

Sylvain Durand, Laetitia Gilet, Ciarán Condon
The essential function of B. subtilis RNase III is to silence foreign toxin genes.
PLoS Genet: 2012, 8(12);e1003181
[PubMed:23300471] [WorldCat.org] [DOI] (I p)

Jessica M Silvaggi, John B Perkins, Richard Losick
Small untranslated RNA antitoxin in Bacillus subtilis.
J Bacteriol: 2005, 187(19);6641-50
[PubMed:16166525] [WorldCat.org] [DOI] (P p)