Difference between revisions of "RNA switch"

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==Important Reviews==
 
==Important Reviews==
  
<pubmed>15063848 , 19385727 19250859 ,19141470 , 17092822, 17764952 ,17381303, 16226486 , 16153177 , 15750802, 14523920  18430893 12029388 19859665 19298181 20230605 </pubmed>
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<pubmed>15063848 , 19385727 19250859 ,19141470 , 17092822, 17764952 ,17381303, 16226486 , 16153177 , 15750802, 14523920  18430893 12029388 19859665 19298181 20230605 20384681 </pubmed>

Revision as of 08:18, 14 April 2010

RNA switches are regulatory systems that rely on alternative mRNA structures.

RNA switches may be triggered by proteins, tRNAs (T-box), or metabolites (riboswitches)

List of Bacillus subtilis RNAswitches

  • Potential additional RNA switches
    • pyrG RNA switch: low levels of intracellular CTP induce reiterative addition of G residues at position +4 in the 5' end of the pyrG mRNA, which is encoded as pppGGGC. . . . The poly(G) sequences formed under these conditions act to prevent attenuation by base pairing with the C- and U-rich 5' strand of a downstream terminator stem-loop located in the pyrG leader. PubMed
    • EAR (eps-associated RNA switch): located between epsB and epsC, mediates processive antitermination and allows expression of the long eps operon PubMed

The function of the following potential RNA structures is unknown. They were suggested to control the mentioned genes.

Important Reviews

Irina Artsimovitch
A processive riboantiterminator seeks a switch to make biofilms.
Mol Microbiol: 2010, 76(3);535-9
[PubMed:20384681] [WorldCat.org] [DOI] (I p)

Zasha Weinberg, Joy X Wang, Jarrod Bogue, Jingying Yang, Keith Corbino, Ryan H Moy, Ronald R Breaker
Comparative genomics reveals 104 candidate structured RNAs from bacteria, archaea, and their metagenomes.
Genome Biol: 2010, 11(3);R31
[PubMed:20230605] [WorldCat.org] [DOI] (I p)

Pascale Romby, Emmanuelle Charpentier
An overview of RNAs with regulatory functions in gram-positive bacteria.
Cell Mol Life Sci: 2010, 67(2);217-37
[PubMed:19859665] [WorldCat.org] [DOI] (I p)

Paul Babitzke, Carol S Baker, Tony Romeo
Regulation of translation initiation by RNA binding proteins.
Annu Rev Microbiol: 2009, 63;27-44
[PubMed:19385727] [WorldCat.org] [DOI] (I p)

Adam Roth, Ronald R Breaker
The structural and functional diversity of metabolite-binding riboswitches.
Annu Rev Biochem: 2009, 78;305-34
[PubMed:19298181] [WorldCat.org] [DOI] (I p)

Michael D Dambach, Wade C Winkler
Expanding roles for metabolite-sensing regulatory RNAs.
Curr Opin Microbiol: 2009, 12(2);161-9
[PubMed:19250859] [WorldCat.org] [DOI] (I p)

Tina M Henkin
Riboswitch RNAs: using RNA to sense cellular metabolism.
Genes Dev: 2008, 22(24);3383-90
[PubMed:19141470] [WorldCat.org] [DOI] (P p)

Jesse C Cochrane, Scott A Strobel
Riboswitch effectors as protein enzyme cofactors.
RNA: 2008, 14(6);993-1002
[PubMed:18430893] [WorldCat.org] [DOI] (I p)

Catherine A Wakeman, Wade C Winkler, Charles E Dann
Structural features of metabolite-sensing riboswitches.
Trends Biochem Sci: 2007, 32(9);415-24
[PubMed:17764952] [WorldCat.org] [DOI] (P p)

Irnov, A Kertsburg, W C Winkler
Genetic control by cis-acting regulatory RNAs in Bacillus subtilis: general principles and prospects for discovery.
Cold Spring Harb Symp Quant Biol: 2006, 71;239-49
[PubMed:17381303] [WorldCat.org] [DOI] (P p)

Frank J Grundy, Tina M Henkin
From ribosome to riboswitch: control of gene expression in bacteria by RNA structural rearrangements.
Crit Rev Biochem Mol Biol: 2006, 41(6);329-38
[PubMed:17092822] [WorldCat.org] [DOI] (P p)

Wade C Winkler
Riboswitches and the role of noncoding RNAs in bacterial metabolic control.
Curr Opin Chem Biol: 2005, 9(6);594-602
[PubMed:16226486] [WorldCat.org] [DOI] (P p)

Wade C Winkler, Ronald R Breaker
Regulation of bacterial gene expression by riboswitches.
Annu Rev Microbiol: 2005, 59;487-517
[PubMed:16153177] [WorldCat.org] [DOI] (P p)

Wade C Winkler
Metabolic monitoring by bacterial mRNAs.
Arch Microbiol: 2005, 183(3);151-9
[PubMed:15750802] [WorldCat.org] [DOI] (P p)

Frank J Grundy, Tina M Henkin
Regulation of gene expression by effectors that bind to RNA.
Curr Opin Microbiol: 2004, 7(2);126-31
[PubMed:15063848] [WorldCat.org] [DOI] (P p)

Wade C Winkler, Ronald R Breaker
Genetic control by metabolite-binding riboswitches.
Chembiochem: 2003, 4(10);1024-32
[PubMed:14523920] [WorldCat.org] [DOI] (P p)

Jörg Stülke
Control of transcription termination in bacteria by RNA-binding proteins that modulate RNA structures.
Arch Microbiol: 2002, 177(6);433-40
[PubMed:12029388] [WorldCat.org] [DOI] (P p)