Difference between revisions of "QdoR"

From SubtiWiki
Jump to: navigation, search
Line 58: Line 58:
  
 
=== Database entries ===
 
=== Database entries ===
 +
* '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU39990&redirect=T BSU39990]
  
 
* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/yxaF.html]
 
* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/yxaF.html]
Line 93: Line 94:
  
 
=== Database entries ===
 
=== Database entries ===
 +
* '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU39990&redirect=T BSU39990]
  
 
* '''Structure:''' [http://www.rcsb.org/pdb/explore.do?structureId=1SGM 1SGM]
 
* '''Structure:''' [http://www.rcsb.org/pdb/explore.do?structureId=1SGM 1SGM]

Revision as of 15:14, 2 April 2014

Gene name qdoR
Synonyms yxaF
Essential no
Product transcriptional regulator
Function control of quercetin utilization
Gene expression levels in SubtiExpress: qdoR
MW, pI 20 kDa, 6.111
Gene length, protein length 573 bp, 191 aa
Immediate neighbours qdoI, yxnA
Sequences Protein DNA DNA_with_flanks
Genetic context
YxaF context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
QdoR expression.png















Categories containing this gene/protein

transcription factors and their control, resistance against other toxic compounds (nitric oxide, phenolic acids, flavonoids, oxalate)

This gene is a member of the following regulons

LmrA regulon, QdoR regulon

The QdoR regulon:

The gene

Basic information

  • Locus tag: BSU39990

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Paralogous protein(s): LmrA

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity: flavonoids such as quercetin act as molecular inducers and result in release from DNA targets PubMed

Database entries

  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Leslie Cuthbertson, Justin R Nodwell
The TetR family of regulators.
Microbiol Mol Biol Rev: 2013, 77(3);440-75
[PubMed:24006471] [WorldCat.org] [DOI] (I p)

Original publications

Kazutake Hirooka, Yasutaro Fujita
Identification of aromatic residues critical to the DNA binding and ligand response of the Bacillus subtilis QdoR (YxaF) repressor antagonized by flavonoids.
Biosci Biotechnol Biochem: 2011, 75(7);1325-34
[PubMed:21737930] [WorldCat.org] [DOI] (I p)

Kazutake Hirooka, Satoshi Kunikane, Hiroshi Matsuoka, Ken-Ichi Yoshida, Kanako Kumamoto, Shigeo Tojo, Yasutaro Fujita
Dual regulation of the Bacillus subtilis regulon comprising the lmrAB and yxaGH operons and yxaF gene by two transcriptional repressors, LmrA and YxaF, in response to flavonoids.
J Bacteriol: 2007, 189(14);5170-82
[PubMed:17483215] [WorldCat.org] [DOI] (P p)

Ken-Ichi Yoshida, Izumi Ishio, Eishi Nagakawa, Yoshiyuki Yamamoto, Mami Yamamoto, Yasutaro Fujita
Systematic study of gene expression and transcription organization in the gntZ-ywaA region of the Bacillus subtilis genome.
Microbiology (Reading): 2000, 146 ( Pt 3);573-579
[PubMed:10746760] [WorldCat.org] [DOI] (P p)