QdoI

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  • Description: Fe-containing quercetin 2,3-dioxygenase

Gene name qdoI
Synonyms yxaG
Essential no
Product Fe-containing quercetin 2,3-dioxygenase
Function resistance to plant product quercetin
MW, pI 37,4 kDa, 5.562
Gene length, protein length 1011 bp, 337 aa
Immediate neighbours yxaH, qdoR
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YxaG context.gif
This image was kindly provided by SubtiList



Categories containing this gene/protein

resistance against other toxic compounds (nitric oxide, phenolic acids, flavonoids, oxalate)

This gene is a member of the following regulons

LmrA regulon, QdoR regulon

The gene

Basic information

  • Locus tag: BSU39980

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: oxidation of the flavonol quercetin with dioxygen, cleaving the central heterocyclic ring and releasing CO
  • Protein family:bicupin family
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s): Mn(II) (preferred), but also active with Fe(II) snd Co(II) PubMed
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

J B Broderick
Catechol dioxygenases.
Essays Biochem: 1999, 34;173-89
[PubMed:10730195] [WorldCat.org] [DOI] (P p)

T D Bugg, J Sanvoisin, E L Spence
Exploring the catalytic mechanism of the extradiol catechol dioxygenases.
Biochem Soc Trans: 1997, 25(1);81-5
[PubMed:9056848] [WorldCat.org] [DOI] (P p)

Original publications