pyrG

168

CTP synthase (NH₃, glutamine)

locus: BSU_37150

Molecular weight: 59.55 kDa

pI: 5.16

Protein length: 535 aa

Gene length: 1608 bp

function: pyrimidine biosynthesis

product: CTP synthase (NH3, glutamine)

essential: yes

ec: 6.3.4.2

synonyms: pyrG, ctrA

List of homologs in different organisms, belongs to COG0504 (Galperin et al., 2021)

Gene

Coordinates: 3,810,693 → 3,812,300

Phenotypes of a mutant

• essential [Pubmed|12682299]

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The protein

Catalyzed reaction/ biological activity

• ATP + H₂O + L-glutamine + UTP --> ADP + CTP + 2 H⁺ + L-glutamate + phosphate (according to UniProt)

Protein family

• CTP synthase family (single member, according to UniProt)

[wiki|Domains]

• [wiki|Glutamine amidotransferase type-1 domain] (aa 292-534) (according to UniProt)

Structure

• [PDB|1VCM] (from ''Thermus thermophilus'', 52% identity, 70% similarity) [Pubmed|15296735]
• [AF|P13242]

Expression and Regulation

additional information

• the mRNA is cleaved by [protein|BAB297D18F94FFA67B8D12A684AB4D1BCDFB4981|RNase III] [PubMed|26883633]

References

Reviews

• 21334966,18535147

Original Publications

• 8206849,17302819,15252202,11544212,1709162,12426364,17158658,2457578,28652344,26883633,29794222,31965171,32973723