pyrE
168
orotate phosphoribosyltransferase
locus
BSU_15560
Molecular weight
23.38 kDa
pI
5.63
function
pyrimidine biosynthesis
product
orotate phosphoribosyltransferase
essential
no
ec
2.4.2.10
synonyms
pyrE, pyrX
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0461 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,629,320 1,629,970
The protein
Catalyzed reaction/ biological activity
diphosphate + orotidine 5'-phosphate --> 5-phospho-α-D-ribose 1-diphosphate + orotate (according to UniProt)
Protein family
[wiki|Purine/pyrimidine phosphoribosyltransferase family] (according to UniProt)
Structure
[PDB|3DEZ] (from ''Streptococcus mutans'', 59% identity, 74% similarity)
[AF|P25972]
Biological materials
Mutant
BKE15560 ([gene|0197A037D2AF049B295E1DA60187D4614B2BAC51|pyrE]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE15560 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TAGATGTTTTGCGATGATTT, downstream forward: _UP4_TAAAAAATAAATTCAAATGA
BKK15560 ([gene|0197A037D2AF049B295E1DA60187D4614B2BAC51|pyrE]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK15560 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TAGATGTTTTGCGATGATTT, downstream forward: _UP4_TAAAAAATAAATTCAAATGA
References
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Time of last update: 2024-04-24 13:50:06
Author of last update: Melvin.boenninger