Difference between revisions of "PurT"

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Revision as of 12:26, 16 May 2013

  • Description: phosphoribosylglycinamide formyltransferase 2

Gene name purT
Synonyms
Essential no
Product phosphoribosylglycinamide formyltransferase 2
Function purine biosynthesis
Gene expression levels in SubtiExpress: purT
Metabolic function and regulation of this protein in SubtiPathways:
Purine synthesis, Nucleotides (regulation)
MW, pI 41 kDa, 4.722
Gene length, protein length 1152 bp, 384 aa
Immediate neighbours ybfI, mpr
Sequences Protein DNA DNA_with_flanks
Genetic context
PurT context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
PurT expression.png




























Categories containing this gene/protein

biosynthesis/ acquisition of nucleotides

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU02230

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: Formate + ATP + 5'-phospho-ribosylglycinamide = 5'-phosphoribosyl-N-formylglycinamide + ADP + diphosphate (according to Swiss-Prot)
  • Protein family: ATP-grasp domain (according to Swiss-Prot)
  • Paralogous protein(s): PurK

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 1KJ9 (with Mg-ATP from Escherichia coli, 55% identity, 69% similarity) PubMed
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Operon: purT (according to DBTBS)
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

H H Saxild, J H Jacobsen, P Nygaard
Functional analysis of the Bacillus subtilis purT gene encoding formate-dependent glycinamide ribonucleotide transformylase.
Microbiology (Reading): 1995, 141 ( Pt 9);2211-8
[PubMed:7496533] [WorldCat.org] [DOI] (P p)