purN
168
phosphoribosylglycinamide formyltransferase, irreversible
locus
BSU_06510
Molecular weight
21.63 kDa
pI
6.18
function
purine biosynthesis
product
phosphoribosylglycinamide formyltransferase
essential
no
ec
2.1.2.2
synonyms
purN
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0299 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
708,010 708,597
The protein
Catalyzed reaction/ biological activity
(6S)-10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide --> (6S)-5,6,7,8-tetrahydrofolate + H+ + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide (according to UniProt)
Protein family
GART family (single member, according to UniProt)
Structure
[PDB|3P9X] (from ''B. halodurans'', 51% identity, 70% similarity)
[AF|P12040]
Paralogous protein(s)
[protein|9A399CAA672C3DF90531A7A7168916DE86EFA365|ykkE]
Biological materials
Mutant
BKE06510 ([gene|7B30F27D6C459437967A64467E52961F4A9E0F2C|purN]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE06510 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TGATGCAAATACCGCAAACT, downstream forward: _UP4_TTAAATAACAGAGGTGAAAA
BKK06510 ([gene|7B30F27D6C459437967A64467E52961F4A9E0F2C|purN]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK06510 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TGATGCAAATACCGCAAACT, downstream forward: _UP4_TTAAATAACAGAGGTGAAAA
References
Page visits: 140119
Time of last update: 2024-04-24 11:23:25
Author of last update: Melvin.boenninger