Difference between revisions of "PurM"

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(Database entries)
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= Categories containing this gene/protein =
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{{SubtiWiki category|[[biosynthesis/ acquisition of nucleotides]]}}
 
=The protein=
 
=The protein=
  

Revision as of 19:05, 30 November 2010

  • Description: phosphoribosylaminoimidazole synthetase

Gene name purM
Synonyms
Essential no
Product phosphoribosylaminoimidazole synthetase
Function purine biosynthesis
Metabolic function and regulation of this protein in SubtiPathways:
Purine synthesis, Nucleotides (regulation)
MW, pI 36 kDa, 4.586
Gene length, protein length 1038 bp, 346 aa
Immediate neighbours purF, purN
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
PurM context.gif
This image was kindly provided by SubtiList







The gene

Basic information

  • Locus tag: BSU06500

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

Categories containing this gene/protein

biosynthesis/ acquisition of nucleotides

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole (according to Swiss-Prot)
  • Protein family: AIR synthase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization: cytoplasm (according to Swiss-Prot)

Database entries

  • Structure: 2BTU (from Bacillus anthracis, 64% identity, 78% similarity)
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
    • repressed in the presence of purine nucleotides (PurR) PubMed
    • repressed in the presence of adenine or adenosine(PurR) PubMed
    • repressed in the presence of guanine(G-box) PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References