PurH

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  • Description: phosphoribosylaminoimidazole carboxamide formyltransferase

Gene name purH
Synonyms purJ
Essential no
Product phosphoribosylaminoimidazole carboxamide formyltransferase

and inosine-monophosphate cyclohydrolase

Function purine biosynthesis
MW, pI 55 kDa, 5.133
Gene length, protein length 1536 bp, 512 aa
Immediate neighbours purN, purD
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
PurH context.gif
This image was kindly provided by SubtiList



The gene

Basic information

  • Locus tag: BSU06520

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: 10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (according to Swiss-Prot)
  • Protein family: purH family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • Structure:
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
    • repressed in the presence of adenine or adenosine(PurR) PubMed
    • repressed in the presence of guanine(G-box) PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

  1. Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed