Difference between revisions of "PurE"

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(Expression and regulation)
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* '''[[Sigma factor]]:''' [[SigA]]
 
* '''[[Sigma factor]]:''' [[SigA]]
  
* '''Regulation:''' induced in the absence of purine nucleotides ([[PurR]])
+
* '''Regulation:'''  
 +
** repressed in the presence of adenine or adenosine([[PurR]])
 +
** repressed in the presence of guanine([[G-box]])
  
* '''Regulatory mechanism:''' [[PurR]]: transcription repression (molecular inducer: PRPP)
+
* '''Regulatory mechanism:'''  
 +
** [[PurR]]: transcription repression (molecular inducer: PRPP)
 +
** [[G-box]]: transcription termination/ antitermination ([[riboswitch]])
  
 
* '''Additional information:'''
 
* '''Additional information:'''

Revision as of 19:36, 31 May 2009

  • Description: phosphoribosylaminoimidazole carboxylase (ATP-dependent)

Gene name purE
Synonyms
Essential no
Product phosphoribosylaminoimidazole carboxylase (ATP-dependent)
Function purine biosynthesis
MW, pI 17 kDa, 5.199
Gene length, protein length 486 bp, 162 aa
Immediate neighbours yebG, purK
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
PurE context.gif
This image was kindly provided by SubtiList



The gene

Basic information

  • Coordinates:

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO2 (according to Swiss-Prot)
  • Protein family: AIR carboxylase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • Structure:

Additional information

Expression and regulation

  • Regulation:
    • repressed in the presence of adenine or adenosine(PurR)
    • repressed in the presence of guanine(G-box)
  • Regulatory mechanism:
    • PurR: transcription repression (molecular inducer: PRPP)
    • G-box: transcription termination/ antitermination (riboswitch)
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

  1. Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed