Difference between revisions of "PurB"

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= [[Categories]] containing this gene/protein =
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{{SubtiWiki category|[[biosynthesis/ acquisition of nucleotides]]}}
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= This gene is a member of the following [[regulons]] =
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{{SubtiWiki regulon|[[G-box]]}},
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{{SubtiWiki regulon|[[PurR regulon]]}}
  
 
=The gene=
 
=The gene=
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= Categories containing this gene/protein =
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{{SubtiWiki category|[[biosynthesis/ acquisition of nucleotides]]}}
 
 
=The protein=
 
=The protein=
  

Revision as of 17:21, 8 December 2010

  • Description: adenylsuccinate lyase

Gene name purB
Synonyms
Essential no
Product adenylsuccinate lyase
Function purine biosynthesis
Metabolic function and regulation of this protein in SubtiPathways:
Purine salvage, Purine synthesis, Nucleotides (regulation), Stress
MW, pI 49 kDa, 5.822
Gene length, protein length 1293 bp, 431 aa
Immediate neighbours purK, purC
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
PurB context.gif
This image was kindly provided by SubtiList







Categories containing this gene/protein

biosynthesis/ acquisition of nucleotides

This gene is a member of the following regulons

G-box, PurR regulon

The gene

Basic information

  • Locus tag: BSU06440

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: N(6)-(1,2-dicarboxyethyl)AMP = fumarate + AMP (according to Swiss-Prot)
  • Protein family: Adenylosuccinate lyase subfamily (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • KEGG entry: [3]

Additional information

  • subject to Clp-dependent proteolysis upon glucose starvation PubMed

Expression and regulation

  • Regulation:
    • repressed in the presence of purine nucleotides (PurR) PubMed
    • repressed in the presence of adenine or adenosine(PurR) PubMed
    • repressed in the presence of guanine(G-box) PubMed
  • Additional information: subject to Clp-dependent proteolysis upon glucose starvation PubMed

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References