psdR

psdR
168

two-component response regulator ([wiki|OmpR family]), induction of [gene|464DD1855E6B3195EE242637612A16C73FF32FC0|psdA]-[gene|AC7F08DC1DF7DD2F9AFF84041D357B286B1244AC|psdB] in response to lipid II-binding lantibiotics (nisin and gallidermin) and internal antimicrobial peptides ([protein|820635420B3980B620F3E3D7ACF7EDE9DC6275AD|sdpC], [protein|DDB0022F50999AC52809D651C9CC5A5FDC71302C|skfA])

locus
BSU_34720
Molecular weight
27.37 kDa
pI
4.68
Protein length
Gene length
function
resistance against toxic peptides
product
two-component response regulator ([wiki|OmpR family])
essential
no
synonyms
psdR, yvcP

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0745 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,567,422  3,568,135
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The protein
Protein family
[wiki|OmpR family] of two-component response regulators
[wiki|Domains]
[wiki|Response regulatory domain] (aa 3-116) (according to UniProt)
Structure
[PDB|5DCL] (from Streptococcus agalactiae, 42% identity) [pubmed|26930060]
[AF|O06978]
Modification
phosphorylated by [protein|A9525886E911164BDFF0A55DA9F5FDD1C1B7A3B6|psdS] on an Asp residue
Effectors of protein activity
phosphorylation likely affects DNA-binding activity
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|985E7F25C809AA5DF372101E64960DF704EED53F|psdR]-[gene|A9525886E911164BDFF0A55DA9F5FDD1C1B7A3B6|psdS]-[gene|464DD1855E6B3195EE242637612A16C73FF32FC0|psdA]-[gene|AC7F08DC1DF7DD2F9AFF84041D357B286B1244AC|psdB]
description
[Pubmed|21078927]
regulation
''[protein|search|psdA]'': induced by nisin, gallidermin ([protein|search|PsdR]) [Pubmed|21078927]
regulatory mechanism
[protein|985E7F25C809AA5DF372101E64960DF704EED53F|psdR]: activation, [Pubmed|21078927], in [regulon|protein:985E7F25C809AA5DF372101E64960DF704EED53F|psdR regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|21078927], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
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[gene|985E7F25C809AA5DF372101E64960DF704EED53F|psdR]→[gene|AC7F08DC1DF7DD2F9AFF84041D357B286B1244AC|psdB]

2024-03-21 09:18:10

ghost

32

d7c5e7b0711e6228a3cdf2a71273ad8f725b7c09

5FD7CD564F41C61165A1333E78C1CCE35B7CF017

Biological materials
Mutant
MGNA-B637 (yvcP::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1636 NBRP B. subtilis, Japan]
BKE34720 ([gene|985E7F25C809AA5DF372101E64960DF704EED53F|psdR]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE34720 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CACGTTGATCCCCCTTATAT,  downstream forward: _UP4_GTCAATCGGAAGGATGAAGC
BKK34720 ([gene|985E7F25C809AA5DF372101E64960DF704EED53F|psdR]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK34720 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CACGTTGATCCCCCTTATAT,  downstream forward: _UP4_GTCAATCGGAAGGATGAAGC
References
10094672,18394148,14651641,21283517,23504016,21078927,26364265,27188294,27997719,26930060

985E7F25C809AA5DF372101E64960DF704EED53F

Page visits: 4558

Time of last update: 2024-03-28 06:10:56

Author of last update: Melvin.boenninger