Difference between revisions of "PsdB"

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m (moved YvcS to PsdB: 21078927)
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* '''Description:''' similar to [[ABC transporter]] (permease) <br/><br/>
+
* '''Description:''' [[ABC transporter]] (permease) for the export of lipid II-binding lantibiotics, such as nisin and gallidermin<br/><br/>
  
 
{| align="right" border="1" cellpadding="2"  
 
{| align="right" border="1" cellpadding="2"  
 
|-
 
|-
 
|style="background:#ABCDEF;" align="center"|'''Gene name'''
 
|style="background:#ABCDEF;" align="center"|'''Gene name'''
|''yvcS''
+
|''psdB''
 
|-
 
|-
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || '' ''
+
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''yvcS ''
 
|-
 
|-
 
|style="background:#ABCDEF;" align="center"| '''Essential''' || no  
 
|style="background:#ABCDEF;" align="center"| '''Essential''' || no  
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|style="background:#ABCDEF;" align="center"| '''Product''' || [[ABC transporter]] (permease)
 
|style="background:#ABCDEF;" align="center"| '''Product''' || [[ABC transporter]] (permease)
 
|-
 
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || resistance to gallidermin
+
|style="background:#ABCDEF;" align="center"|'''Function''' || export of toxic peptides
 
|-
 
|-
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 73 kDa, 9.804   
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 73 kDa, 9.804   
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|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 1938 bp, 646 aa  
 
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 1938 bp, 646 aa  
 
|-
 
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[yvcT]]'', ''[[yvcR]]''
+
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[yvcT]]'', ''[[psdA]]''
 
|-
 
|-
 
|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+&#91;EMBLCDS:CAB15474&#93;+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
 
|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+&#91;EMBLCDS:CAB15474&#93;+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
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* '''Effectors of protein activity:'''
 
* '''Effectors of protein activity:'''
  
* '''Interactions:''' [[YvcR]]-[[YvcS]] {{PubMed|10092453}}
+
* '''Interactions:''' [[PsdA]]-[[PsdB]] {{PubMed|10092453}}
 
   
 
   
 
* '''Localization:''' cell membrane (according to Swiss-Prot)
 
* '''Localization:''' cell membrane (according to Swiss-Prot)
Line 87: Line 87:
  
 
=Expression and regulation=
 
=Expression and regulation=
* '''Operon:''' ''[[yvcR]]-[[yvcS]]'' {{PubMed|18394148}}  
+
* '''Operon:'''  
 +
** ''[[psdA]]-[[psdB]]'' {{PubMed|18394148}}
 +
** ''[[psdR]]-[[psdS]]-[[psdA]]-[[psdB]]'' {{PubMed|21078927}}  
  
 
* '''[[Sigma factor]]:'''  
 
* '''[[Sigma factor]]:'''  
 +
** ''[[psdA]]'': [[SigA]] {{PubMed|21078927}}
 +
** ''[[psdR]]'': [[SigA]] {{PubMed|21078927}}
  
 
* '''Regulation:'''  
 
* '''Regulation:'''  
** induced by nisin, gallidermin {{PubMed|18394148}}
+
** ''[[psdA]]'': induced by nisin, gallidermin ([[PsdR]]) {{PubMed|21078927}}  
  
 
* '''Regulatory mechanism:'''  
 
* '''Regulatory mechanism:'''  
 +
** [[PsdR]]: transcription activation {{PubMed|21078927}}
  
 
* '''Additional information:'''
 
* '''Additional information:'''
Line 118: Line 123:
 
=References=
 
=References=
  
<pubmed>18394148,10092453,, </pubmed>
+
<pubmed>18394148,10092453,21078927, </pubmed>
  
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 18:18, 17 November 2010

  • Description: ABC transporter (permease) for the export of lipid II-binding lantibiotics, such as nisin and gallidermin

Gene name psdB
Synonyms yvcS
Essential no
Product ABC transporter (permease)
Function export of toxic peptides
MW, pI 73 kDa, 9.804
Gene length, protein length 1938 bp, 646 aa
Immediate neighbours yvcT, psdA
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YvcS context.gif
This image was kindly provided by SubtiList



The gene

Basic information

  • Locus tag: BSU34690

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: ABC-4 integral membrane protein family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Localization: cell membrane (according to Swiss-Prot)

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Anna Staroń, Dora Elisabeth Finkeisen, Thorsten Mascher
Peptide antibiotic sensing and detoxification modules of Bacillus subtilis.
Antimicrob Agents Chemother: 2011, 55(2);515-25
[PubMed:21078927] [WorldCat.org] [DOI] (I p)

Eva Rietkötter, Diana Hoyer, Thorsten Mascher
Bacitracin sensing in Bacillus subtilis.
Mol Microbiol: 2008, 68(3);768-85
[PubMed:18394148] [WorldCat.org] [DOI] (I p)

Y Quentin, G Fichant, F Denizot
Inventory, assembly and analysis of Bacillus subtilis ABC transport systems.
J Mol Biol: 1999, 287(3);467-84
[PubMed:10092453] [WorldCat.org] [DOI] (P p)