psd

168

phosphatidylserine decarboxylase

locus: BSU_02290

Molecular weight: 29.54 kDa

pI: 7.27

Protein length: 263 aa

Gene length: 792 bp

function: biosynthesis of phosphatidylethanolamine

product: phosphatidylserine decarboxylase

essential: no

ec: 4.1.1.65

synonyms: psd

List of homologs in different organisms, belongs to COG0688 (Galperin et al., 2021)

Gene

Coordinates: 248,749 → 249,540

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The protein

Catalyzed reaction/ biological activity

• 1,2-diacyl-sn-glycero-3-phospho-L-serine + H⁺ --> 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO² (according to UniProt)

Protein family

• phosphatidylserine decarboxylase family (single member, according to UniProt)

Structure

• [PDB|6L06] (from E. coli, corresponds to aa 26 ... 208, 29.1% identity) [pubmed|32402247]
• [AF|P39822]

[wiki|Localization]

• cell membrane at the septum [Pubmed|15743965]

Biological materials

Mutant

• BKE02290 (Δ[gene|F34915697F3EF05E6A683055F46346C73F25CAFC|psd]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE02290 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_TATTAAACATGAATAATCCC,  downstream forward: _UP4_TAAAAAGAGGAGCTTGCATA
• BKK02290 (Δ[gene|F34915697F3EF05E6A683055F46346C73F25CAFC|psd]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK02290 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_TATTAAACATGAATAATCCC,  downstream forward: _UP4_TAAAAAGAGGAGCTTGCATA

References

• 14762009,18820022,9422599,15743965,32402247