Difference between revisions of "Protein kinases and phosphatases"

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(Protein serine kinases)
 
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These enzymes phosphorylate or dephosphorylate other [[phosphoproteins|proteins]].
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These enzymes phosphorylate or dephosphorylate other [[phosphoproteins|proteins]]. By definition, they use ATP (or GTP) as the phosphoryl group donor (as opposed to phosphotransferases of the [[PTS|phosphotranferase system]] and the [[phosphorelay]]).
  
 
==Protein kinases==
 
==Protein kinases==
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===Protein arginine kinases===
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* [[McsB]] 
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===Protein serine kinases===
 
===Protein serine kinases===
 
* [[HprK]] (has also phosphorylase activity)
 
* [[HprK]] (has also phosphorylase activity)
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* [[CotH]]
 
* [[PrkC]]
 
* [[PrkC]]
 
* [[PrkD]]
 
* [[PrkD]]
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* [[YabT]]
 
* [[YabT]]
  
===Protein tyrosine kinases===
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===Protein tyrosine kinases (see the [http://bykdb.ibcp.fr/BYKdb/BYKdbHelp Bacterial Protein Tyrosine Kinase Database])===
 
* [[PtkA]]
 
* [[PtkA]]
 
* [[EpsB]]: similar to [[PtkA]], but has probably no kinase activity
 
* [[EpsB]]: similar to [[PtkA]], but has probably no kinase activity
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 +
===Protein kinases of [[two-component systems]]===
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* [[ComP]]
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* [[DegS]]
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* [[DesK]]
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* [[LiaS]]
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* [[YdfH]]
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* [[YfiJ]]
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* [[YhcY]]
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* [[YvfT]]
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* [[YxjM]]
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* [[BceS]]
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* [[CssS]]
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* [[NatK]]
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* [[PhoR]]
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* [[ResE]]
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* [[WalK]]
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* [[YbdK]]
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* [[YcbM]]
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* [[YclK]]
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* [[YkoH]]
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* [[YrkO]]
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* [[YvcQ]]
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* [[YvrG]]
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* [[YxdK]]
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* [[CheA]]
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* [[CitS]]
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* [[DctS]]
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* [[GlnK]]
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* [[MalK]]
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* [[LytS]]
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* [[YesM]]
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* [[YwpD]]
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* [[KinA]]
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* [[KinB]]
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* [[KinC]]
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* [[KinD]]
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* [[KinE]]
  
 
==Protein phosphatases==
 
==Protein phosphatases==
 +
===Protein arginine phosphatases===
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* [[YwlE]]
 +
 
===Protein serine phosphatases===
 
===Protein serine phosphatases===
 
* [[PrpC]]
 
* [[PrpC]]
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* [[RsbX]]
 
* [[RsbX]]
 
* [[SpoIIE]]
 
* [[SpoIIE]]
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===Protein tyrosine phosphatases===
 
===Protein tyrosine phosphatases===
 
* [[PtpZ]]
 
* [[PtpZ]]
 
* [[YfkJ]]
 
* [[YfkJ]]
* [[YwlE]]
 
  
==Related Lists==
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===Protein aspartate phosphatases controlling the [[phosphorelay]] ===
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* [[Spo0E]]: dephosphorylation of [[Spo0A]]
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* [[YisI]]: dephosphorylation of [[Spo0A]]
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* [[YnzD]]: dephosphorylation of [[Spo0A]]
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* [[RapA]]: dephosphorylation of [[Spo0F]]
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* [[RapB]]: dephosphorylation of [[Spo0F]]
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* [[RapE]]: dephosphorylation of [[Spo0F]]
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* [[RapH]]: dephosphorylation of [[Spo0F]]
 +
 
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=Related Lists=
 
* [[phosphoproteins]]
 
* [[phosphoproteins]]
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* [[protein modification]]
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* [[two-component systems]]
  
 
=Reviews=
 
=Reviews=
<pubmed> 16209347 </pubmed>
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<pubmed> 16209347 21372323 23731382 25625314</pubmed>

Latest revision as of 16:59, 19 May 2016

These enzymes phosphorylate or dephosphorylate other proteins. By definition, they use ATP (or GTP) as the phosphoryl group donor (as opposed to phosphotransferases of the phosphotranferase system and the phosphorelay).

Protein kinases

Protein arginine kinases

Protein serine kinases

Protein tyrosine kinases (see the Bacterial Protein Tyrosine Kinase Database)

  • PtkA
  • EpsB: similar to PtkA, but has probably no kinase activity

Protein kinases of two-component systems

Protein phosphatases

Protein arginine phosphatases

Protein serine phosphatases

Protein tyrosine phosphatases

Protein aspartate phosphatases controlling the phosphorelay

Related Lists

Reviews

Jonathan Dworkin
Ser/Thr phosphorylation as a regulatory mechanism in bacteria.
Curr Opin Microbiol: 2015, 24;47-52
[PubMed:25625314] [WorldCat.org] [DOI] (I p)

Charlotte Cousin, Abderahmane Derouiche, Lei Shi, Yves Pagot, Sandrine Poncet, Ivan Mijakovic
Protein-serine/threonine/tyrosine kinases in bacterial signaling and regulation.
FEMS Microbiol Lett: 2013, 346(1);11-9
[PubMed:23731382] [WorldCat.org] [DOI] (I p)

Sandro F F Pereira, Lindsie Goss, Jonathan Dworkin
Eukaryote-like serine/threonine kinases and phosphatases in bacteria.
Microbiol Mol Biol Rev: 2011, 75(1);192-212
[PubMed:21372323] [WorldCat.org] [DOI] (I p)

Michał Obuchowski
[Serine-threonine protein phosphatases from Bacillus subtilis]. [Serynowo-treoninowe fosfatazy białkowe w Bacillus subtilis.]
Postepy Biochem: 2005, 51(1);95-104
[PubMed:16209347] [WorldCat.org] (P p)