Difference between revisions of "PolX"
(New page: * '''Description:''' write here <br/><br/> {| align="right" border="1" cellpadding="2" |- |style="background:#ABCDEF;" align="center"|'''Gene name''' |''yshC'' |- |style="background:#ABC...) |
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| − | * '''Description:''' | + | * '''Description:''' DNA polymerase X, involved in DNA repair <br/><br/> |
{| align="right" border="1" cellpadding="2" | {| align="right" border="1" cellpadding="2" | ||
|- | |- | ||
|style="background:#ABCDEF;" align="center"|'''Gene name''' | |style="background:#ABCDEF;" align="center"|'''Gene name''' | ||
| − | |'' | + | |''polX'' |
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"| '''Synonyms''' || '' '' | + | |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''yshC '' |
|- | |- | ||
|style="background:#ABCDEF;" align="center"| '''Essential''' || | |style="background:#ABCDEF;" align="center"| '''Essential''' || | ||
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"| '''Product''' || | + | |style="background:#ABCDEF;" align="center"| '''Product''' || DNA polymerase X |
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"|'''Function''' || | + | |style="background:#ABCDEF;" align="center"|'''Function''' || involved in base excision repair |
|- | |- | ||
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 63 kDa, 5.308 | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 63 kDa, 5.308 | ||
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=== Basic information/ Evolution === | === Basic information/ Evolution === | ||
| − | * '''Catalyzed reaction/ biological activity:''' | + | * '''Catalyzed reaction/ biological activity:''' template-dependent DNA polymerase, fills single nucleotide gaps [http://www.ncbi.nlm.nih.gov/sites/entrez/18938175 PubMed], has intrinsic 3'-5' exonuclease activity for resecting unannealed 3'-termini in gapped DNA substrates [http://www.ncbi.nlm.nih.gov/sites/entrez/18776221 PubMed] |
| − | * '''Protein family:''' | + | * '''Protein family:''' DNA polymerase X family |
* '''Paralogous protein(s):''' | * '''Paralogous protein(s):''' | ||
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* '''Effectors of protein activity:''' | * '''Effectors of protein activity:''' | ||
| − | * '''Interactions:''' | + | * '''Interactions:''' monomeric [http://www.ncbi.nlm.nih.gov/sites/entrez/18938175 PubMed] |
* '''Localization:''' | * '''Localization:''' | ||
| Line 113: | Line 113: | ||
=Labs working on this gene/protein= | =Labs working on this gene/protein= | ||
| + | |||
| + | [[Margarita Salas]], Madrid, Spain | ||
=Your additional remarks= | =Your additional remarks= | ||
| Line 118: | Line 120: | ||
=References= | =References= | ||
| − | # | + | # Banos et al. (2008) Characterization of a Bacillus subtilis 64 kDa DNA polymerase X potentially involved in DNA repair. ''J. Mol. Biol.'' '''384:''' 1019-1028. [http://www.ncbi.nlm.nih.gov/sites/entrez/18938175 PubMed] |
| + | # Banos et al. (2008) Editing of misaligned 3'-termini by an intrinsic 3'-5' exonuclease activity residing in the PHP domain of a family X DNA polymerase. ''Nucl. Acids Res.'' '''36:''' 5736-5749. [http://www.ncbi.nlm.nih.gov/sites/entrez/18776221 PubMed] | ||
Revision as of 14:48, 30 January 2009
- Description: DNA polymerase X, involved in DNA repair
| Gene name | polX |
| Synonyms | yshC |
| Essential | |
| Product | DNA polymerase X |
| Function | involved in base excision repair |
| MW, pI | 63 kDa, 5.308 |
| Gene length, protein length | 1710 bp, 570 aa |
| Immediate neighbours | |
| Gene sequence (+200bp) | Protein sequence |
Genetic context 
| |
Contents
The gene
Basic information
- Coordinates:
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: template-dependent DNA polymerase, fills single nucleotide gaps PubMed, has intrinsic 3'-5' exonuclease activity for resecting unannealed 3'-termini in gapped DNA substrates PubMed
- Protein family: DNA polymerase X family
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions: monomeric PubMed
- Localization:
Database entries
- Structure:
- Swiss prot entry:
- KEGG entry:
- E.C. number:
Additional information
Expression and regulation
- Operon:
- Sigma factor:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Margarita Salas, Madrid, Spain
Your additional remarks
References
- Banos et al. (2008) Characterization of a Bacillus subtilis 64 kDa DNA polymerase X potentially involved in DNA repair. J. Mol. Biol. 384: 1019-1028. PubMed
- Banos et al. (2008) Editing of misaligned 3'-termini by an intrinsic 3'-5' exonuclease activity residing in the PHP domain of a family X DNA polymerase. Nucl. Acids Res. 36: 5736-5749. PubMed
