PlsC

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  • Description: acyl-ACP:1-acylglycerolphosphate acyltransferase

Gene name plsC
Synonyms yhdO
Essential yes PubMed
Product acyl-ACP:1-acylglycerolphosphate acyltransferase
Function biosynthesis of phospholipids
Gene expression levels in SubtiExpress: plsC
Metabolic function and regulation of this protein in SubtiPathways:
plsC
MW, pI 21 kDa, 9.976
Gene length, protein length 597 bp, 199 aa
Immediate neighbours yhdN, yhdP
Sequences Protein DNA DNA_with_flanks
Genetic context
YhdO context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
PlsC expression.png




























Categories containing this gene/protein

biosynthesis of lipids, general stress proteins (controlled by SigB), essential genes, membrane proteins

This gene is a member of the following regulons

FapR regulon, SigB regulon

The gene

Basic information

  • Locus tag: BSU09540

Phenotypes of a mutant

essential PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Lucía Porrini, Larisa E Cybulski, Silvia G Altabe, María C Mansilla, Diego de Mendoza
Cerulenin inhibits unsaturated fatty acids synthesis in Bacillus subtilis by modifying the input signal of DesK thermosensor.
Microbiologyopen: 2014, 3(2);213-24
[PubMed:24574048] [WorldCat.org] [DOI] (I p)

Luciana Paoletti, Ying-Jie Lu, Gustavo E Schujman, Diego de Mendoza, Charles O Rock
Coupling of fatty acid and phospholipid synthesis in Bacillus subtilis.
J Bacteriol: 2007, 189(16);5816-24
[PubMed:17557823] [WorldCat.org] [DOI] (P p)

Ayako Nishibori, Jin Kusaka, Hiroshi Hara, Masato Umeda, Kouji Matsumoto
Phosphatidylethanolamine domains and localization of phospholipid synthases in Bacillus subtilis membranes.
J Bacteriol: 2005, 187(6);2163-74
[PubMed:15743965] [WorldCat.org] [DOI] (P p)

Gustavo E Schujman, Luciana Paoletti, Alan D Grossman, Diego de Mendoza
FapR, a bacterial transcription factor involved in global regulation of membrane lipid biosynthesis.
Dev Cell: 2003, 4(5);663-72
[PubMed:12737802] [WorldCat.org] [DOI] (P p)