pksE
168
involved in polyketide synthesis
locus
BSU_17120
Molecular weight
85.61 kDa
pI
7.38
function
polyketide synthesis
product
unknown
essential
no
synonyms
pksE
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG2070 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,786,104 → 1,788,407
The protein
Catalyzed reaction/ biological activity
holo-[ACP] + malonyl-CoA --> CoA + malonyl-[ACP] (according to UniProt)
Protein family
fabD family (with [protein|55C821F68B2E5F9F45CC2B2C9494D48D5C33266A|pksC] and [protein|BB8542A6444564B21FF5DB6E2C75192C6DA2DFB8|fabD], according to UniProt)
Structure
[PDB|5DZ7] (N-terminal domain, aa 1 ... 288)
[PDB|4CW5] (C-terminal domain, from B. amyloliquefaciens, corresponds to aa 315 ... 753, 59% identity) [pubmed|25456814]
[AF|O34787]
Biological materials
Mutant
BKE17120 (Δ[gene|CB0B856B22984DD5B10F01DD07C3961FAA742923|pksE]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE17120 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TTGCCCTGGAAAGACATATG, downstream forward: _UP4_TGAATATTATGAAAATATAC
BKK17120 (Δ[gene|CB0B856B22984DD5B10F01DD07C3961FAA742923|pksE]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK17120 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TTGCCCTGGAAAGACATATG, downstream forward: _UP4_TGAATATTATGAAAATATAC
References
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Time of last update: 2024-04-24 06:24:47
Author of last update: Melvin.boenninger