PhrI

• Description: response regulator aspartate phosphatase (RapI) regulator
  
  

Gene name	phrI
Synonyms
Essential	no
Product	phosphatase (RapI) regulator
Function	control of the transfer of the mobile genetic element ICEBs1
MW, pI	4 kDa, 8.907
Gene length, protein length	117 bp, 39 aa
Immediate neighbours	rapI, yddM
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU05020

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: binds RapI and inhibits its activity, this results in contiuned repression of the genes for the transfer of the mobile genetic element ICEBs1 by ImmR PubMed

• Protein family: phr family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions: PhrI-RapI PubMed

• Localization:

Database entries

• Structure:

• UniProt: O31492

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon:
  • rapI-phrI PubMed
  • phrI PubMed

• Sigma factor:
  • phrI: SigA, SigH PubMed

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Jennifer M Auchtung, Catherine A Lee, Katherine L Garrison, Alan D Grossman
Identification and characterization of the immunity repressor (ImmR) that controls the mobile genetic element ICEBs1 of Bacillus subtilis.
Mol Microbiol: 2007, 64(6);1515-28
[PubMed:17511812] [WorldCat.org] [DOI] (P p)

R S McQuade, N Comella, A D Grossman
Control of a family of phosphatase regulatory genes (phr) by the alternate sigma factor sigma-H of Bacillus subtilis.
J Bacteriol: 2001, 183(16);4905-9
[PubMed:11466295] [WorldCat.org] [DOI] (P p)