Difference between revisions of "PhrC"

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(Database entries)
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* '''Structure:'''
 
* '''Structure:'''
 +
** [http://www.rcsb.org/pdb/explore/explore.do?structureId=4GYO 4GYO] (complex [[RapJ]]-[[PhrC]]) {{PubMed|23526881}}
  
 
* '''UniProt:''' [http://www.uniprot.org/uniprot/P94416 P94416]
 
* '''UniProt:''' [http://www.uniprot.org/uniprot/P94416 P94416]

Revision as of 17:38, 27 March 2013

Gene name phrC
Synonyms
Essential no
Product phosphatase (RapC) regulator /
competence and sporulation stimulating factor (CSF)
Function control of ComA activity
Gene expression levels in SubtiExpress: phrC
Interactions involving this protein in SubtInteract: PhrC
MW, pI 4 kDa, 8.16
Gene length, protein length 120 bp, 40 aa
Immediate neighbours rapC, yczM
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
PhrC context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
PhrC expression.png















Categories containing this gene/protein

genetic competence, transcription factors and their control, quorum sensing, short peptides

This gene is a member of the following regulons

CcpA regulon, CodY regulon, ComA regulon, SigH regulon

The gene

Basic information

  • Locus tag: BSU03780

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: binds to RapC, this results in the inability of RapC to interact with ComA PubMed
  • Protein family: phr family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • repressed during growth in the presence of branched chain amino acids (CodY) PubMed
    • repressed by glucose (4.5-fold) (CcpA) PubMed
    • expressed at high cell density (ComA) PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Elizabeth Anne Shank, Roberto Kolter
Extracellular signaling and multicellularity in Bacillus subtilis.
Curr Opin Microbiol: 2011, 14(6);741-7
[PubMed:22024380] [WorldCat.org] [DOI] (I p)

Original publications