Difference between revisions of "PhrA"

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* '''Description:''' [[response regulator aspartate phosphatase]] ([[RapA]]) inhibitor, control of the [[phosphorelay]] <br/><br/>
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|style="background:#ABCDEF;" align="center"|'''Function''' || control of sporulation initiation  
 
|style="background:#ABCDEF;" align="center"|'''Function''' || control of sporulation initiation  
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://cellpublisher.gobics.de/subtiexpress/ ''Subti''Express]''': [http://cellpublisher.gobics.de/subtiexpress/bsu/BSU12440 phrA]
 
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://cellpublisher.gobics.de/subtinteract/startpage/start/ ''Subt''Interact]''': [http://cellpublisher.gobics.de/subtinteract/interactionList/2/PhrA PhrA]
 
|colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://cellpublisher.gobics.de/subtinteract/startpage/start/ ''Subt''Interact]''': [http://cellpublisher.gobics.de/subtinteract/interactionList/2/PhrA PhrA]

Revision as of 08:07, 7 August 2012


Gene name phrA
Synonyms gsiAB
Essential no
Product phosphatase (RapA) inhibitor
Function control of sporulation initiation
Gene expression levels in SubtiExpress: phrA
Interactions involving this protein in SubtInteract: PhrA
Function and regulation of this protein in SubtiPathways:
Phosphorelay
MW, pI 4 kDa, 10.229
Gene length, protein length 132 bp, 44 aa
Immediate neighbours rapA, yjpA
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
PhrA context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
PhrA expression.png




























Categories containing this gene/protein

phosphorelay, quorum sensing, short peptides

This gene is a member of the following regulons

CodY regulon, ComA regulon, Spo0A regulon

The gene

Basic information

  • Locus tag: BSU12440

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: phr family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • repressed by glucose (4.2-fold) (CcpA) PubMed
    • repressed by casamino acids PubMed
    • repressed under conditions that trigger sporulation (Spo0A) PubMed
    • repressed during growth in the presence of branched chain amino acids (CodY) PubMed
    • expressed at high cell density (ComA) PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Additional publications: PubMed