Difference between revisions of "Phosphotransferase systems"

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* 1.2.3. [[Transporters/ other]]
 
* 1.2.3. [[Transporters/ other]]
 
|Related=
 
|Related=
none
+
* [[PRD-containing transcription factors]]
 +
* [[transport proteins]]
 +
* [[trigger enzymes]]
 
|}}
 
|}}
  
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* [http://subtiwiki.uni-goettingen.de/pathways/carbon_flow.html Central C-metabolism]
 
* [http://subtiwiki.uni-goettingen.de/pathways/carbon_flow.html Central C-metabolism]
 
* [http://subtiwiki.uni-goettingen.de/pathways/carbohydrate_metabolic_pathways.html Sugar catabolism]
 
* [http://subtiwiki.uni-goettingen.de/pathways/carbohydrate_metabolic_pathways.html Sugar catabolism]
 
==Related Lists==
 
* [[PRD-containing transcription factors]]
 
* [[transport proteins]]
 
* [[trigger enzymes]]
 
  
 
==Relevant Reviews==
 
==Relevant Reviews==
 
<pubmed>17158705 9871918 9663674 10627040 11532441 16339738 </pubmed>
 
<pubmed>17158705 9871918 9663674 10627040 11532441 16339738 </pubmed>

Revision as of 11:14, 12 November 2010

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The PEP:Sugar Phosphotransferase System

The PTS is a sugar transport system that couples the transport of a sugar to its phosphorylation. The phosphate group is derived from phosphoenolpyruvate (PEP) and transferred via the general PTS proteins Enzyme I (EI) and HPr to the substrate-specific Enzymes II (EII) to the incoming sugars.

In addition to its role in sugar transport, the PTS is also involved in the regulation of carbon metabolism.

General PTS proteins

Sugar specific PTS proteins

  • PtsG: glucose permease, EIICBA
  • GamP: glucosamine permease, EIICBA
  • MurP: N-acetyl muramic acid-specific phosphotransferase system, EIIBC component
  • MtlA, MtlF: mannitol permease
  • GmuA, GmuB, GmuC: galactomannan permease
  • TreP: trehalose permease
  • MalP: maltose permease
  • FruA: fructose permease
  • ManP: mannose permease
  • NagP: N-acetylglucosamine permease, EIICB component
  • LevD, LevE, LevF, LevG: fructose permease
  • SacP: sucrose permease (high affinity)
  • SacY: sucrose permease (low affinity)
  • LicA, LicB, LicC: lichenan permease
  • BglP: ß-glucoside permease
  • YpqE: unknown EIIA component
  • YwbA: unknown EIIC component
  • YyzE: unknown PTS protein

Proteins closely related to the PTS

  • Crh: HPr-like protein with exculsively regulatory functions (His-15 is not conserved
  • HprK: HPr-kinase, key factor for carbon catabolite repression

Non-PTS proteins controlled by PTS-dependent phosphorylation

The PTS in SubtiPathways

Relevant Reviews