Difference between revisions of "PheA"

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=Expression and regulation=
 
=Expression and regulation=
  
* '''Operon:''' ''[[pheB]]-[[pheA]]''
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* '''Operon:''' ''[[pheB]]-[[pheA]]'' {{PubMed|2537815}}
  
 
* '''[[Sigma factor]]:'''  
 
* '''[[Sigma factor]]:'''  
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=References=
 
=References=
 
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<pubmed>19258532 2537815  </pubmed>
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 18:40, 13 December 2009

  • Description: prephenate dehydratase

Gene name pheA
Synonyms
Essential no
Product prephenate dehydratase
Function biosynthesis of phenylalanine
Metabolic function and regulation of this protein in SubtiPathways:
Phe, Tyr, Trp
MW, pI 31 kDa, 5.886
Gene length, protein length 855 bp, 285 aa
Immediate neighbours nadR, pheB
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
PheA context.gif
This image was kindly provided by SubtiList







The gene

Basic information

  • Locus tag: BSU27900

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: Prephenate = phenylpyruvate + H2O + CO2 (according to Swiss-Prot)
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity: subject to feedback inhibition PubMed
  • Interactions:
  • Localization:

Database entries

  • Structure:
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information: subject to feedback inhibition PubMed

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Ana Gutiérrez-Preciado, Tina M Henkin, Frank J Grundy, Charles Yanofsky, Enrique Merino
Biochemical features and functional implications of the RNA-based T-box regulatory mechanism.
Microbiol Mol Biol Rev: 2009, 73(1);36-61
[PubMed:19258532] [WorldCat.org] [DOI] (I p)

K Trach, J A Hoch
The Bacillus subtilis spo0B stage 0 sporulation operon encodes an essential GTP-binding protein.
J Bacteriol: 1989, 171(3);1362-71
[PubMed:2537815] [WorldCat.org] [DOI] (P p)