PfeT

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  • Description: zinc transporter

Gene name zosA
Synonyms ykvW
Essential no
Product P-type zinc-transporting ATPase
Function zinc uptake
Gene expression levels in SubtiExpress: zosA
MW, pI 68 kDa, 4.934
Gene length, protein length 1911 bp, 637 aa
Immediate neighbours stoA, papB
Sequences Protein DNA DNA_with_flanks
Genetic context
YkvW context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
ZosA expression.png















Categories containing this gene/protein

transporters/ other, trace metal homeostasis (Cu, Zn, Ni, Mn, Mo), membrane proteins

This gene is a member of the following regulons

PerR regulon

The gene

Basic information

  • Locus tag: BSU13850

Phenotypes of a mutant

    • reduced genetic competence, can be rescued by the addition of excess zinc PubMed
    • reduced expression of comK, control is exerted at the post-transcriptional level and can be rescued by the addition of excess zinc PubMed

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: ATP + H2O + Zn2+(In) = ADP + phosphate + Zn2+(Out) (according to Swiss-Prot) P-type zinc-transporting ATPase PubMed
  • Protein family: Type IB subfamily (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [2]

Additional information

Expression and regulation

  • Regulation: induced by hydrogen peroxide (PerR) PubMed
  • Regulatory mechanism:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References