Difference between revisions of "PdxK"

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* '''Description:''' phosphomethylpyrimidine kinase <br/><br/>
+
* '''Description:''' pyridoxal kinase <br/><br/>
  
 
{| align="right" border="1" cellpadding="2"  
 
{| align="right" border="1" cellpadding="2"  
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|style="background:#ABCDEF;" align="center"| '''Essential''' || no  
 
|style="background:#ABCDEF;" align="center"| '''Essential''' || no  
 
|-
 
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || phosphomethylpyrimidine kinase
+
|style="background:#ABCDEF;" align="center"| '''Product''' || pyridoxal kinase
 
|-
 
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || biosynthesis of thiamine
+
|style="background:#ABCDEF;" align="center"|'''Function''' || biosynthesis of pyridoxal phosphate
 
|-
 
|-
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 28 kDa, 4.922   
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 28 kDa, 4.922   

Revision as of 09:19, 11 May 2009

  • Description: pyridoxal kinase

Gene name thiD
Synonyms ywdB, ipa-52r
Essential no
Product pyridoxal kinase
Function biosynthesis of pyridoxal phosphate
MW, pI 28 kDa, 4.922
Gene length, protein length 813 bp, 271 aa
Immediate neighbours ywdD, ywdA
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
ThiD context.gif
This image was kindly provided by SubtiList



The gene

Basic information

  • Coordinates:

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s): YjbV

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • KEGG entry: [3]
  • E.C. number:

Additional information

  • subject to Clp-dependent proteolysis upon glucose starvation PubMed

Expression and regulation

  • Operon:
  • Regulation:
  • Regulatory mechanism:
  • Additional information: subject to Clp-dependent proteolysis upon glucose starvation PubMed

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

  1. Gerth et al. (2008) Clp-dependent proteolysis down-regulates central metabolic pathways in glucose-starved Bacillus subtilis. J Bacteriol 190:321-331 PubMed
  2. Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed