Difference between revisions of "Pdp"

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(Expression and regulation)
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=Expression and regulation=
 
=Expression and regulation=
 +
* '''Operon:''' ''[[dra]]-[[nupC]]-[[pdp]]'' {{PubMed|8550462}}
  
* '''Operon:'''  
+
* '''[[Sigma factor]]:''' [[SigA]] {{PubMed|8550462}}
  
* '''[[Sigma factor]]:'''
+
* '''Regulation:'''
 +
** repressed by glucose ([[CcpA]]) {{PubMed|10666464}}
 +
** induced by deoxynucleotides ([[DeoR]]) {{PubMed|8550462}}
  
* '''Regulation:''' repressed by glucose ([[CcpA]]
+
* '''Regulatory mechanism:'''  
 
+
** [[CcpA]]: transcription repression {{PubMed|10666464}}
* '''Regulatory mechanism:''' [[CcpA]]: transcription repression  
+
** [[DeoR]]: transcription repression {{PubMed|8550462}}
  
 
* '''Additional information:'''
 
* '''Additional information:'''
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=References=
 
=References=
  
<pubmed>,11065368,8550462,10074062, </pubmed>
+
<pubmed>,11065368,8550462,10074062, 10666464 </pubmed>
  
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 19:19, 8 February 2010

  • Description: pyrimidine nucleoside phosphorylase

Gene name pdp
Synonyms
Essential no
Product pyrimidine nucleoside phosphorylase
Function pyrimidine interconversion
Metabolic function and regulation of this protein in SubtiPathways:
Nucleoside catabolism, Nucleotides (regulation)
MW, pI 46 kDa, 4.765
Gene length, protein length 1299 bp, 433 aa
Immediate neighbours hutM, nupC
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
Pdp context.gif
This image was kindly provided by SubtiList







The gene

Basic information

  • Locus tag: BSU39400

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: A pyrimidine nucleoside + phosphate = a pyrimidine base + alpha-D-ribose 1-phosphate (according to Swiss-Prot)
  • Protein family: thymidine/pyrimidine-nucleoside phosphorylase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • Structure: 1BRW (Geobacillus stearothermophilus)
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Xianmin Zeng, Anne Galinier, Hans H Saxild
Catabolite repression of dra-nupC-pdp operon expression in Bacillus subtilis.
Microbiology (Reading): 2000, 146 ( Pt 11);2901-2908
[PubMed:11065368] [WorldCat.org] [DOI] (P p)

Y Miwa, A Nakata, A Ogiwara, M Yamamoto, Y Fujita
Evaluation and characterization of catabolite-responsive elements (cre) of Bacillus subtilis.
Nucleic Acids Res: 2000, 28(5);1206-10
[PubMed:10666464] [WorldCat.org] [DOI] (I p)

X Zeng, H H Saxild
Identification and characterization of a DeoR-specific operator sequence essential for induction of dra-nupC-pdp operon expression in Bacillus subtilis.
J Bacteriol: 1999, 181(6);1719-27
[PubMed:10074062] [WorldCat.org] [DOI] (P p)

H H Saxild, L N Andersen, K Hammer
Dra-nupC-pdp operon of Bacillus subtilis: nucleotide sequence, induction by deoxyribonucleosides, and transcriptional regulation by the deoR-encoded DeoR repressor protein.
J Bacteriol: 1996, 178(2);424-34
[PubMed:8550462] [WorldCat.org] [DOI] (P p)