Difference between revisions of "PapA"

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|style="background:#ABCDEF;" align="center"|'''Function''' || degradation of proline-containing peptides
 
|style="background:#ABCDEF;" align="center"|'''Function''' || degradation of proline-containing peptides
 
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://cellpublisher.gobics.de/subtiexpress/ ''Subti''Express]''': [http://cellpublisher.gobics.de/subtiexpress/bsu/BSU24460 papA]
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU24460 papA]
 
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/other_nitrogen_sources/index.html Alternative nitrogen sources]'''
 
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/other_nitrogen_sources/index.html Alternative nitrogen sources]'''
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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[efp]]'', ''[[yqhS]]''
 
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[efp]]'', ''[[yqhS]]''
 
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|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+&#91;EMBLCDS:CAB14377&#93;+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
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|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU24460 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU24460 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU24460 Advanced_DNA]
 
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|colspan="2" | '''Genetic context''' <br/> [[Image:yqhT_context.gif]]
 
|colspan="2" | '''Genetic context''' <br/> [[Image:yqhT_context.gif]]

Revision as of 13:16, 13 May 2013

  • Description: Xaa-Pro amino-peptidase

Gene name papA
Synonyms yqhT
Essential no
Product Xaa-Pro amino-peptidase
Function degradation of proline-containing peptides
Gene expression levels in SubtiExpress: papA
Metabolic function and regulation of this protein in SubtiPathways:
Alternative nitrogen sources
MW, pI 37 kDa, 4.83
Gene length, protein length 1059 bp, 353 aa
Immediate neighbours efp, yqhS
Sequences Protein DNA Advanced_DNA
Genetic context
YqhT context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
YqhT expression.png















Categories containing this gene/protein

utilization of nitrogen sources other than amino acids, coping with hyper-osmotic stress

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU24460

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: peptidase M24B family (according to Swiss-Prot)
  • Paralogous protein(s): PapB

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 3Q6D (the B. anthracis enzyme, 65% identity, 82% similarity)
  • KEGG entry: [2]

Additional information

Expression and regulation

  • Operon:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Erhard Bremer, Marburg University, Germany Homepage

Your additional remarks

References

Adrienne Zaprasis, Jeanette Brill, Marietta Thüring, Guido Wünsche, Magnus Heun, Helena Barzantny, Tamara Hoffmann, Erhard Bremer
Osmoprotection of Bacillus subtilis through import and proteolysis of proline-containing peptides.
Appl Environ Microbiol: 2013, 79(2);576-87
[PubMed:23144141] [WorldCat.org] [DOI] (I p)