PaiA

• Description: spermine/spermidine-N-acetyltransferase
  
  

Gene name	paiA
Synonyms
Essential	no
Product	spermine/spermidine-N-acetyltransferase
Function	control of intracellular polyamine concentrations
Gene expression levels in SubtiExpress: paiA
Interactions involving this protein in SubtInteract: PaiA
MW, pI	19 kDa, 5.018
Gene length, protein length	516 bp, 172 aa
Immediate neighbours	paiB, sufA
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

miscellaneous metabolic pathways

The gene

Basic information

• Locus tag: BSU32150

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • AprE-PaiA PubMed

• Localization:

Database entries

• Structure: 1TIQ

• UniProt: P21340

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Expression browser: paiA PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Farhad Forouhar, Alexandre Kuzin, Jayaraman Seetharaman, Insun Lee, Weihong Zhou, Mariam Abashidze, Yang Chen, Wei Yong, Haleema Janjua, Yingyi Fang, Dongyan Wang, Kellie Cunningham, Rong Xiao, Thomas B Acton, Eran Pichersky, Daniel F Klessig, Carl W Porter, Gaetano T Montelione, Liang Tong
Functional insights from structural genomics.
J Struct Funct Genomics: 2007, 8(2-3);37-44
[PubMed:17588214] [WorldCat.org] [DOI] (P p)

Farhad Forouhar, In-Sun Lee, Jelena Vujcic, Slavoljub Vujcic, Jianwei Shen, Sergey M Vorobiev, Rong Xiao, Thomas B Acton, Gaetano T Montelione, Carl W Porter, Liang Tong
Structural and functional evidence for Bacillus subtilis PaiA as a novel N1-spermidine/spermine acetyltransferase.
J Biol Chem: 2005, 280(48);40328-36
[PubMed:16210326] [WorldCat.org] [DOI] (P p)

T Urano, H Ihara, K Umemura, Y Suzuki, M Oike, S Akita, Y Tsukamoto, I Suzuki, A Takada
The profibrinolytic enzyme subtilisin NAT purified from Bacillus subtilis Cleaves and inactivates plasminogen activator inhibitor type 1.
J Biol Chem: 2001, 276(27);24690-6
[PubMed:11325965] [WorldCat.org] [DOI] (P p)