pabB

pabB
168

para-aminobenzoate synthase (subunit A)

locus
BSU_00740
Molecular weight
53.09 kDa
pI
5.23
Protein length
Gene length
function
biosynthesis of folate
product
para-aminobenzoate synthase (subunit A)
essential
no
ec
2.6.1.85
synonyms
pabB, pab

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0147 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
82,864 → 84,276
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The protein
Catalyzed reaction/ biological activity
Chorismate + L-glutamine --> 4-amino-4-deoxychorismate + L-glutamate (according to UniProt)
Protein family
Anthranilate synthase component I family (with [protein|48C33A96F3B446440D4D9A86AA07AA3BA244063D|trpE], according to UniProt)
Structure
[PDB|5CWA] (from ''Mycobacterium tuberculosis'', 39% identity) [Pubmed|26527146]
[AF|P28820]
Expression and Regulation
Operons
genes
[gene|B189AD3E3D18876E1956763182D835A151727392|pabB]-[gene|956E33AAAADB302EB8663E4B75C917242D3AD2C0|pabA]-[gene|865678B10097C40337F5EEA77FF0F6E7BF5358DC|pabC]-[gene|FA9539CB701BC47FD4E849FBA6D7B201B27C6104|sul]-[gene|AAE44B4F73C7C02F7DB3574B6169E0DE46F4B787|folB]-[gene|D2B189C6292ACE1B25658B407C284E9A683EAE5B|folK]-[gene|F373EBC35805DC551E8AFF6FDC7E43D5587C4700|yazB]-[gene|CE45D56BC413555AF4E7914B5307AD967A358452|yacF]-[gene|24CC89DE55B3C19F80B11D106B9FD241174AE3E4|lysS]
description
[Pubmed|9084182]
regulation
translation repressed by tryptophan ([protein|E030E80134E9DED6ADBC73C7C7435024CDFD38B9|mtrB]) [Pubmed|9084182]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|9084182], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
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[gene|B189AD3E3D18876E1956763182D835A151727392|pabB]→[gene|24CC89DE55B3C19F80B11D106B9FD241174AE3E4|lysS]

2024-03-14 03:48:43

Jstuelk

73

8c465dd3eec1aaa32d5e91206834f9bb99ef474a

7B9041CE94396BF42D285F7C0EDD3A2544761EEE

Biological materials
Mutant
BKE00740 (Δ[gene|B189AD3E3D18876E1956763182D835A151727392|pabB]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE00740 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATTTGTATCATTCCTCTAT,  downstream forward: _UP4_AAAATTAGATGAGGTGAGCG
BKK00740 (Δ[gene|B189AD3E3D18876E1956763182D835A151727392|pabB]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK00740 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATTTGTATCATTCCTCTAT,  downstream forward: _UP4_AAAATTAGATGAGGTGAGCG
References
9084182,26527146

B189AD3E3D18876E1956763182D835A151727392

Page visits: 2992

Time of last update: 2024-03-28 14:19:13

Author of last update: Melvin.boenninger