PTS

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The PEP:Sugar Phosphotransferase System

The PTS is a sugar transport system that couples the transport of a sugar to its phosphorylation. The phosphate group is derived from phosphoenolpyruvate (PEP) and transferred via the general PTS proteins Enzyme I (EI) and HPr to the substrate-specific Enzymes II (EII) to the incoming sugars.

In addition to its role in sugar transport, the PTS is also involved in the regulation of carbon metabolism.

General PTS proteins

Sugar specific PTS proteins

Proteins closely related to the PTS

    • Crh: HPr-like protein with exculsively regulatory functions (His-15 is not conserved)
    • HprK: HPr-kinase, key factor for carbon catabolite repression

Non-PTS proteins controlled by PTS-dependent phosphorylation

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