Difference between revisions of "NupO"
| Line 1: | Line 1: | ||
| − | * '''Description:''' | + | * '''Description:''' [[ABC transporter]] for guanosine (ATP-binding protein) <br/><br/> |
{| align="right" border="1" cellpadding="2" | {| align="right" border="1" cellpadding="2" | ||
| Line 10: | Line 10: | ||
|style="background:#ABCDEF;" align="center"| '''Essential''' || no | |style="background:#ABCDEF;" align="center"| '''Essential''' || no | ||
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"| '''Product''' || | + | |style="background:#ABCDEF;" align="center"| '''Product''' || [[ABC transporter]] for guanosine |
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"|'''Function''' || | + | |style="background:#ABCDEF;" align="center"|'''Function''' || uptake of guanosine |
|- | |- | ||
|colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://cellpublisher.gobics.de/subtinteract/startpage/start/ ''Subt''Interact]''': [http://cellpublisher.gobics.de/subtinteract/interactionList/2/YufO YufO] | |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://cellpublisher.gobics.de/subtinteract/startpage/start/ ''Subt''Interact]''': [http://cellpublisher.gobics.de/subtinteract/interactionList/2/YufO YufO] | ||
| Line 35: | Line 35: | ||
= [[Categories]] containing this gene/protein = | = [[Categories]] containing this gene/protein = | ||
{{SubtiWiki category|[[ABC transporters]]}}, | {{SubtiWiki category|[[ABC transporters]]}}, | ||
| + | {{SubtiWiki category|[[biosynthesis/ acquisition of nucleotides]]}}, | ||
{{SubtiWiki category|[[membrane proteins]]}} | {{SubtiWiki category|[[membrane proteins]]}} | ||
| Line 47: | Line 48: | ||
===Phenotypes of a mutant === | ===Phenotypes of a mutant === | ||
| + | * a ''[[nupO]] [[nupG]]'' double mutant is unable to utilize externally provided guanosine {{PubMed|21926227}} | ||
=== Database entries === | === Database entries === | ||
| Line 98: | Line 100: | ||
=Expression and regulation= | =Expression and regulation= | ||
| + | * '''Operon:''' ''[[nupN]]-[[nupO]]-[[nupP]]-[[nupQ]]'' {{PubMed|21926227}} | ||
| − | * ''' | + | * '''[[Sigma factor]]:''' [[SigA]] {{PubMed|21926227}} |
| − | * '''[[ | + | * '''Regulation:''' |
| + | ** repressed during growth in the presence of branched chain amino acids ([[CodY]]) {{PubMed|12618455,21699902,21926227}} | ||
| − | + | * '''Regulatory mechanism:''' | |
| − | + | ** [[CodY]]: transcription repression {{PubMed|12618455,21699902,21926227}} | |
| − | |||
| − | * '''Regulatory mechanism:''' | ||
| − | ** [[CodY]]: transcription repression | ||
* '''Additional information:''' | * '''Additional information:''' | ||
| Line 131: | Line 132: | ||
=References= | =References= | ||
| − | <pubmed>10092453,,12618455, </pubmed> | + | <pubmed>10092453,21926227,12618455, </pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 16:39, 20 September 2011
- Description: ABC transporter for guanosine (ATP-binding protein)
| Gene name | yufO |
| Synonyms | |
| Essential | no |
| Product | ABC transporter for guanosine |
| Function | uptake of guanosine |
| Interactions involving this protein in SubtInteract: YufO | |
| MW, pI | 56 kDa, 7.497 |
| Gene length, protein length | 1530 bp, 510 aa |
| Immediate neighbours | yufN, yufP |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
Categories containing this gene/protein
ABC transporters, biosynthesis/ acquisition of nucleotides, membrane proteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU31550
Phenotypes of a mutant
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: ABC transporter family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
Database entries
- Structure:
- UniProt: O05253
- KEGG entry: [2]
- E.C. number:
Additional information
Expression and regulation
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Boris R Belitsky, Abraham L Sonenshein
CodY-mediated regulation of guanosine uptake in Bacillus subtilis.
J Bacteriol: 2011, 193(22);6276-87
[PubMed:21926227]
[WorldCat.org]
[DOI]
(I p)
Virginie Molle, Yoshiko Nakaura, Robert P Shivers, Hirotake Yamaguchi, Richard Losick, Yasutaro Fujita, Abraham L Sonenshein
Additional targets of the Bacillus subtilis global regulator CodY identified by chromatin immunoprecipitation and genome-wide transcript analysis.
J Bacteriol: 2003, 185(6);1911-22
[PubMed:12618455]
[WorldCat.org]
[DOI]
(P p)
Y Quentin, G Fichant, F Denizot
Inventory, assembly and analysis of Bacillus subtilis ABC transport systems.
J Mol Biol: 1999, 287(3);467-84
[PubMed:10092453]
[WorldCat.org]
[DOI]
(P p)
