nupG

nupG
168

purine nucleoside transporter

locus
BSU_39020
Molecular weight
43.56 kDa
pI
7.76
Protein length
Gene length
function
purine uptake
product
purine nucleoside transporter
essential
no
synonyms
nupG, yxjA

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1972 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
4,005,752 → 4,006,945
Phenotypes of a mutant
a ''[gene|19BA45BD691BBA4B23C4741C63DB729AA5D30FDA|nupN] [gene|C333F405F597FF260FFA0EC616B8CF6BF454815B|nupG]'' double mutant is unable to utilize externally provided guanosine [Pubmed|21926227]
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The protein
Protein family
concentrative nucleoside transporter (CNT) (TC 2.A.41) family (with [protein|4F718681A7AD0C86B2551248570F493AC0B2E7E9|nupC] and [protein|7D4CF2FF4108D3AE170C1EE3C7D494EAD46699C6|yutK], according to UniProt)
Structure
[PDB|3TIJ] (from Vibrio cholerae, 25% identity) [pubmed|22407322]
[AF|P42312]
[wiki|Localization]
cell membrane [Pubmed|18763711]
Expression and Regulation
Operons
genes
[gene|C333F405F597FF260FFA0EC616B8CF6BF454815B|nupG]
regulation
expression activated by glucose (4.3 fold) [Pubmed|12850135]
the [wiki|G-box] RNA is degraded by [protein|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y] [pubmed|29794222]
regulatory mechanism
G-box: RNA switch, [Pubmed|12923093], in [regulon|other_regulator:G-box|G-box]
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[gene|C333F405F597FF260FFA0EC616B8CF6BF454815B|nupG]

2024-03-17 04:18:02

Jstuelk

49

2f0b85cd60a5cd47069160021b260a70074c6c71

6BD9E161ECE9FD7B7670AB4A04A99C484C85844B

Biological materials
Mutant
MGNA-B725 (yxjA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1724 NBRP B. subtilis, Japan]
CS219 (''[gene|C333F405F597FF260FFA0EC616B8CF6BF454815B|nupG]''::''aphA3'', available in [wiki|Colin Harwood]'s and [wiki|Jörg Stülke]'s labs) [Pubmed|27197833]
BKE39020 (Δ[gene|C333F405F597FF260FFA0EC616B8CF6BF454815B|nupG]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE39020 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATGATAGCAACTCCTATGA,  downstream forward: _UP4_TAGAAACATTGAGCCATATC
BKK39020 (Δ[gene|C333F405F597FF260FFA0EC616B8CF6BF454815B|nupG]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK39020 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATGATAGCAACTCCTATGA,  downstream forward: _UP4_TAGAAACATTGAGCCATATC
References
12850135,18763711,12923093,21926227,27197833,22407322,29794222,35348734,35622174

C333F405F597FF260FFA0EC616B8CF6BF454815B

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Time of last update: 2024-03-28 20:02:44

Author of last update: Jstuelk