Difference between revisions of "Nth"

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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ypoC]]'', ''[[dnaD]]''
 
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ypoC]]'', ''[[dnaD]]''
 
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|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU22340 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU22340 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU22340 Advanced_DNA]
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|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU22340 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU22340 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU22340 DNA_with_flanks]
 
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|colspan="2" | '''Genetic context''' <br/> [[Image:nth_context.gif]]
 
|colspan="2" | '''Genetic context''' <br/> [[Image:nth_context.gif]]

Revision as of 10:33, 14 May 2013

  • Description: endonuclease III, removes abasic sites during base excision repair

Gene name nth
Synonyms jooB, ypoB
Essential no
Product endonuclease III
Function DNA repair
Gene expression levels in SubtiExpress: nth
MW, pI 24 kDa, 9.277
Gene length, protein length 657 bp, 219 aa
Immediate neighbours ypoC, dnaD
Sequences Protein DNA DNA_with_flanks
Genetic context
Nth context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
Nth expression.png
























Categories containing this gene/protein

DNA repair/ recombination

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU22340

Phenotypes of a mutant

  • the mutant is sensititive to exposure to H2O2 PubMed

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate (according to Swiss-Prot)
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 1P59 (complex with DNA, Geobacillus stearothermophilus)
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Sigma factor:
  • Regulation:
    • constitutively expressed PubMed
    • expression is transiently increased after treatment with H2O2 PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References