ntdA
168
pyridoxal phosphate-dependent 3-oxo-glucose-6-phosphate:glutamate aminotransferase
locus
BSU_10550
Molecular weight
49.98 kDa
pI
5.97
function
synthesis of the antibiotic kanosamine
product
pyridoxal phosphate-dependent
essential
no
synonyms
ntdA, yhjL
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0399 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,128,286 1,129,611
The protein
Catalyzed reaction/ biological activity
3-oxo-d-glucose-6-phosphate + glutamate --> kanosamine-6-phosphate [Pubmed|23586652]
Protein family
DegT/DnrJ/EryC1 family (with [protein|0D24AB8D446CFFBC6DEAD3C10D1FA59551545FE8|epsN] and [protein|38DBA751456A0C0EC5D028939ADB8860ADA28F94|spsC], according to UniProt)
[wiki|Cofactors]
pyridoxalphosphate [Pubmed|23586652]
Structure
[PDB|4K2I] [Pubmed|24097983]
[AF|O07566]
Biological materials
Mutant
MGNA-A725 (yhjL::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/725 NBRP B. subtilis, Japan]
BKE10550 ([gene|2F850E2DFA6287DB3890243803E06FDE7ACDB10E|ntdA]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE10550 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGAACAGTACCTCCAATG, downstream forward: _UP4_TTTCATGTTATTAAGCAAGA
BKK10550 ([gene|2F850E2DFA6287DB3890243803E06FDE7ACDB10E|ntdA]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK10550 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGAACAGTACCTCCAATG, downstream forward: _UP4_TTTCATGTTATTAAGCAAGA
References
Reviews
Original Publications
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Time of last update: 2024-04-24 10:21:09
Author of last update: Jstuelk