Difference between revisions of "NsrR"
| Line 68: | Line 68: | ||
* '''Modification:''' | * '''Modification:''' | ||
| − | * '''Cofactor(s):''' | + | * '''Cofactor(s):''' [4Fe-4S] cluster, required for DNA-binding {{PubMed|21091510}} |
| − | * '''Effectors of protein activity:''' nitric oxide (NO) acts as molecular inducer and results in NsrR release from its DNA targets {{PubMed|19006327}} | + | * '''Effectors of protein activity:''' |
| + | ** nitric oxide (NO) acts as molecular inducer and results in NsrR release from its DNA targets {{PubMed|19006327}} | ||
| + | ** [4Fe-4S]-NsrR binds around the -35 element of the ''[[nasD]]'' promoter with much higher affinity than apo-NsrR and binding of [4Fe-4S]-NsrR, but not apo-protein, is sensitive to NO {{PubMed|21091510}} | ||
* '''Interactions:''' | * '''Interactions:''' | ||
| Line 120: | Line 122: | ||
=References= | =References= | ||
| − | <pubmed>16885456, | + | <pubmed>16885456,,17293416,21091510 , </pubmed> |
| − | + | Additional publications: {{PubMed|19006327}} | |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 13:14, 28 November 2010
- Description: nitric oxide-responsive regulator
| Gene name | nsrR |
| Synonyms | yhdE |
| Essential | no |
| Product | transcriptional repressor |
| Function | repression of ResD-ResE-dependent genes in the absence of nitric oxide (NO) |
| Metabolic function and regulation of this protein in SubtiPathways: Stress | |
| MW, pI | 16 kDa, 7.75 |
| Gene length, protein length | 438 bp, 146 aa |
| Immediate neighbours | lytF, ygxB |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
The gene
Basic information
- Locus tag: BSU09380
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s): [4Fe-4S] cluster, required for DNA-binding PubMed
- Effectors of protein activity:
- Interactions:
- Localization:
Database entries
- Structure:
- UniProt: O07573
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Operon: nsrR PubMed
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Sushma Kommineni, Erik Yukl, Takahiro Hayashi, Jacob Delepine, Hao Geng, Pierre Moënne-Loccoz, Michiko M Nakano
Nitric oxide-sensitive and -insensitive interaction of Bacillus subtilis NsrR with a ResDE-controlled promoter.
Mol Microbiol: 2010, 78(5);1280-93
[PubMed:21091510]
[WorldCat.org]
[DOI]
(I p)
Annika Rogstam, Jonas T Larsson, Peter Kjelgaard, Claes von Wachenfeldt
Mechanisms of adaptation to nitrosative stress in Bacillus subtilis.
J Bacteriol: 2007, 189(8);3063-71
[PubMed:17293416]
[WorldCat.org]
[DOI]
(P p)
Michiko M Nakano, Hao Geng, Shunji Nakano, Kazuo Kobayashi
The nitric oxide-responsive regulator NsrR controls ResDE-dependent gene expression.
J Bacteriol: 2006, 188(16);5878-87
[PubMed:16885456]
[WorldCat.org]
[DOI]
(P p)
Additional publications: PubMed
