Noc

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  • Description: DNA-binding protein, spatial regulator of cell division to protect the nucleoid, and timing device with an important role in the coordination of chromosome segregation and cell division

Gene name noc
Synonyms yyaA
Essential no
Product effector of nucleoid occlusion
Function control of cell division
MW, pI 32 kDa, 5.812
Gene length, protein length 849 bp, 283 aa
Immediate neighbours yyaB, gidB
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YyaA context.gif
This image was kindly provided by SubtiList



The gene

Basic information

  • Locus tag: BSU40990

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: binds specific sites on the chromosome PubMed
  • Protein family: ParB family (according to Swiss-Prot)
  • Paralogous protein(s): Spo0J

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization: cytoplasm (according to Swiss-Prot)

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Jeff Errington, Newcastle, UK Homepage

Your additional remarks

References

Ling Juan Wu, Shu Ishikawa, Yoshikazu Kawai, Taku Oshima, Naotake Ogasawara, Jeff Errington
Noc protein binds to specific DNA sequences to coordinate cell division with chromosome segregation.
EMBO J: 2009, 28(13);1940-52
[PubMed:19494834] [WorldCat.org] [DOI] (I p)

Yoshikazu Kawai, Naotake Ogasawara
Bacillus subtilis EzrA and FtsL synergistically regulate FtsZ ring dynamics during cell division.
Microbiology (Reading): 2006, 152(Pt 4);1129-1141
[PubMed:16549676] [WorldCat.org] [DOI] (P p)

Ling Juan Wu, Jeff Errington
Coordination of cell division and chromosome segregation by a nucleoid occlusion protein in Bacillus subtilis.
Cell: 2004, 117(7);915-25
[PubMed:15210112] [WorldCat.org] [DOI] (P p)

Jörg Sievers, Brian Raether, Marta Perego, Jeff Errington
Characterization of the parB-like yyaA gene of Bacillus subtilis.
J Bacteriol: 2002, 184(4);1102-11
[PubMed:11807071] [WorldCat.org] [DOI] (P p)

  1. Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed