Difference between revisions of "Nin"

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|style="background:#ABCDEF;" align="center"| '''Essential''' || no  
 
|style="background:#ABCDEF;" align="center"| '''Essential''' || no  
 
|-
 
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || inhibitor of the DNA degrading activity of NucA  
+
|style="background:#ABCDEF;" align="center"| '''Product''' || inhibitor of the DNA degrading activity of [[NucA]]
 
|-
 
|-
 
|style="background:#ABCDEF;" align="center"|'''Function''' || genetic transformation, DNA uptake
 
|style="background:#ABCDEF;" align="center"|'''Function''' || genetic transformation, DNA uptake
 +
|-
 +
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/wiki/index.php/Protein_secretion Protein secretion]'''
 
|-
 
|-
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 14 kDa, 4.922   
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 14 kDa, 4.922   

Revision as of 14:16, 11 December 2010

  • Description: inhibitor of the DNA degrading activity of NucA

Gene name nin
Synonyms comJ
Essential no
Product inhibitor of the DNA degrading activity of NucA
Function genetic transformation, DNA uptake
Metabolic function and regulation of this protein in SubtiPathways:
Protein secretion
MW, pI 14 kDa, 4.922
Gene length, protein length 396 bp, 132 aa
Immediate neighbours yckE, nucA
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
Nin context.gif
This image was kindly provided by SubtiList



Categories containing this gene/protein

genetic competence, membrane proteins

This gene is a member of the following regulons

ComK regulon

The gene

Basic information

  • Locus tag: BSU03420

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization: cell membrane (according to Swiss-Prot)

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism: ComK: transcription activation PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Hanne Jarmer, Randy Berka, Steen Knudsen, Hans H Saxild
Transcriptome analysis documents induced competence of Bacillus subtilis during nitrogen limiting conditions.
FEMS Microbiol Lett: 2002, 206(2);197-200
[PubMed:11814663] [WorldCat.org] [DOI] (P p)

R Provvedi, I Chen, D Dubnau
NucA is required for DNA cleavage during transformation of Bacillus subtilis.
Mol Microbiol: 2001, 40(3);634-44
[PubMed:11359569] [WorldCat.org] [DOI] (P p)

D van Sinderen, R Kiewiet, G Venema
Differential expression of two closely related deoxyribonuclease genes, nucA and nucB, in Bacillus subtilis.
Mol Microbiol: 1995, 15(2);213-23
[PubMed:7746143] [WorldCat.org] [DOI] (P p)