Difference between revisions of "NifZ"

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* '''Description:''' [[NifS]] protein homolog, putative cysteine desulfurase<br/><br/>
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* '''Description:''' cysteine desulfurase<br/><br/>
  
 
{| align="right" border="1" cellpadding="2"  
 
{| align="right" border="1" cellpadding="2"  
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|style="background:#ABCDEF;" align="center"| '''Essential''' || no  
 
|style="background:#ABCDEF;" align="center"| '''Essential''' || no  
 
|-
 
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || putative cysteine desulfurase
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|style="background:#ABCDEF;" align="center"| '''Product''' || cysteine desulfurase
 
|-
 
|-
 
|style="background:#ABCDEF;" align="center"|'''Function''' || thiamine biosynthesis
 
|style="background:#ABCDEF;" align="center"|'''Function''' || thiamine biosynthesis
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=== Additional information===
 
=== Additional information===
 
 
  
  
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* '''Protein family:'''
 
* '''Protein family:'''
  
* '''Paralogous protein(s):'''  [[NifS]], [[YrvO]], [[Csd]]
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* '''Paralogous protein(s):'''  [[NifS]], [[YrvO]], [[SufS]], [[YcbU]]
  
 
=== Extended information on the protein ===
 
=== Extended information on the protein ===
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* '''Effectors of protein activity:'''
 
* '''Effectors of protein activity:'''
  
* '''Interactions:'''
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* '''[[SubtInteract|Interactions]]:'''
  
 
* '''Localization:'''
 
* '''Localization:'''

Revision as of 09:15, 2 July 2011

  • Description: cysteine desulfurase

Gene name nifZ
Synonyms iscSB
Essential no
Product cysteine desulfurase
Function thiamine biosynthesis
Metabolic function and regulation of this protein in SubtiPathways:
Thiamin
MW, pI 41 kDa, 6.34
Gene length, protein length 1143 bp, 381 aa
Immediate neighbours ytbJ, braB
Gene sequence (+200bp) Protein sequence
Genetic context
NifZ context.gif
This image was kindly provided by SubtiList





Categories containing this gene/protein

biosynthesis of cofactors

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU29590

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Localization:

Database entries

  • Structure: 1EG5 (NifS-like protein from Thermotoga maritima, 35% identity, 55% similarity) PubMed
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Christopher T Jurgenson, Tadhg P Begley, Steven E Ealick
The structural and biochemical foundations of thiamin biosynthesis.
Annu Rev Biochem: 2009, 78;569-603
[PubMed:19348578] [WorldCat.org] [DOI] (I p)

Original publications

J T Kaiser, T Clausen, G P Bourenkow, H D Bartunik, S Steinbacher, R Huber
Crystal structure of a NifS-like protein from Thermotoga maritima: implications for iron sulphur cluster assembly.
J Mol Biol: 2000, 297(2);451-64
[PubMed:10715213] [WorldCat.org] [DOI] (P p)