NhaC

• Description: Na+/H+ antiporter
  
  

Gene name	nhaC
Synonyms	yheL
Essential	no
Product	Na+/H+ antiporter
Function	pH homeostasis
MW, pI	47 kDa, 7.874
Gene length, protein length	1359 bp, 453 aa
Immediate neighbours	dat, nhaX
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

transporters/ other, metal ion homeostasis (K, Na, Ca, Mg), pH homeostasis, membrane proteins

The gene

Basic information

• Locus tag: BSU09680

Expression

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: nhaC Na(+)/H(+) antiporter family (according to Swiss-Prot)

• Paralogous protein(s): MleN

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cell membrane (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: O07553

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon: nhaC PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:
  • NhaX: transcription activation (probably) PubMed

• Additional information:
  • the mRNA is substantially stabilized upon depletion of RNase Y PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Lehnik-Habrink M, Schaffer M, Mäder U, Diethmaier C, Herzberg C, Stülke J  
RNA processing in Bacillus subtilis: identification of targets of the essential RNase Y. 
Mol Microbiol. 2011 81(6): 1459-1473. 
PubMed:21815947

Z Prágai, C Eschevins, S Bron, C R Harwood
Bacillus subtilis NhaC, an Na+/H+ antiporter, influences expression of the phoPR operon and production of alkaline phosphatases.
J Bacteriol: 2001, 183(8);2505-15
[PubMed:11274110] [WorldCat.org] [DOI] (P p)