Difference between revisions of "NdoA"

From SubtiWiki
Jump to: navigation, search
Line 30: Line 30:
  
 
<br/><br/>
 
<br/><br/>
 +
 +
= [[Categories]] containing this gene/protein =
 +
{{SubtiWiki category|[[Rnases]]}},
 +
{{SubtiWiki category|[[toxins, antitoxins and immunity against toxins]]}}
 +
 +
= This gene is a member of the following [[regulons]] =
 +
  
 
=The gene=
 
=The gene=
Line 49: Line 56:
  
  
= Categories containing this gene/protein =
+
 
{{SubtiWiki category|[[Rnases]]}},
 
{{SubtiWiki category|[[toxins, antitoxins and immunity against toxins]]}}
 
 
=The protein=
 
=The protein=
  

Revision as of 16:57, 8 December 2010

  • Description: RNase EndoA, MazF family toxin, cleaves cellular mRNAs at specific, but frequently occuring sites

Gene name ndoA
Synonyms ydcE
Essential no
Product endoribonuclease EndoA, MazF family toxin
Function plasmid partition
MW, pI 12 kDa, 4.892
Gene length, protein length 348 bp, 116 aa
Immediate neighbours ndoAI, rsbR
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YdcE context.gif
This image was kindly provided by SubtiList



Categories containing this gene/protein

Rnases, toxins, antitoxins and immunity against toxins

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU04660

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: pemK family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity: the activity is inhibited by the interaction with NdoAI PubMed
  • Localization:

Database entries

  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Shivangi Agarwal, Shivani Agarwal, Rakesh Bhatnagar
Identification and characterization of a novel toxin-antitoxin module from Bacillus anthracis.
FEBS Lett: 2007, 581(9);1727-34
[PubMed:17416361] [WorldCat.org] [DOI] (P p)

Olivier Pellegrini, Nathalie Mathy, Arhonda Gogos, Lawrence Shapiro, Ciarán Condon
The Bacillus subtilis ydcDE operon encodes an endoribonuclease of the MazF/PemK family and its inhibitor.
Mol Microbiol: 2005, 56(5);1139-48
[PubMed:15882409] [WorldCat.org] [DOI] (P p)