NatR

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Gene name natR
Synonyms yccH
Essential no
Product two-component response regulator
Function regulation of the natA-natB operon
Gene expression levels in SubtiExpress: natR
Interactions involving this protein in SubtInteract: NatR
MW, pI 26 kDa, 6.614
Gene length, protein length 699 bp, 233 aa
Immediate neighbours natK, natA
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YccH context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
NatR expression.png

























Categories containing this gene/protein

metal ion homeostasis (K, Na, Ca, Mg), transcription factors and their control, phosphoproteins

This gene is a member of the following regulons

The NatR regulon:

The gene

Basic information

  • Locus tag: BSU02740

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: OmpR family of two-component response regulators
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification: phosphorylated by NatK on an Asp residue
  • Cofactor(s):
  • Effectors of protein activity: phosphorylation likely affects DNA-binding activity

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Operon: natR (according to DBTBS)
  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Mitsuo Ogura, Kensuke Tsukahara, Kentaro Hayashi, Teruo Tanaka
The Bacillus subtilis NatK-NatR two-component system regulates expression of the natAB operon encoding an ABC transporter for sodium ion extrusion.
Microbiology (Reading): 2007, 153(Pt 3);667-675
[PubMed:17322186] [WorldCat.org] [DOI] (P p)

C Fabret, V A Feher, J A Hoch
Two-component signal transduction in Bacillus subtilis: how one organism sees its world.
J Bacteriol: 1999, 181(7);1975-83
[PubMed:10094672] [WorldCat.org] [DOI] (P p)