NatA

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Gene name natA
Synonyms
Essential no
Product Na+ ABC transporter (export) (ATP-binding protein)
Function sodium export
Gene expression levels in SubtiExpress: natA
Interactions involving this protein in SubtInteract: NatA
MW, pI 27 kDa, 8.799
Gene length, protein length 738 bp, 246 aa
Immediate neighbours natR, natB
Sequences Protein DNA DNA_with_flanks
Genetic context
NatA context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
NatA expression.png

























Categories containing this gene/protein

ABC transporters, metal ion homeostasis (K, Na, Ca, Mg), membrane proteins

This gene is a member of the following regulons

NatR regulon

The gene

Basic information

  • Locus tag: BSU02750

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Sigma factor:
  • Regulation:
  • Regulatory mechanism: NatR: transcription activation PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Mitsuo Ogura, Kensuke Tsukahara, Kentaro Hayashi, Teruo Tanaka
The Bacillus subtilis NatK-NatR two-component system regulates expression of the natAB operon encoding an ABC transporter for sodium ion extrusion.
Microbiology (Reading): 2007, 153(Pt 3);667-675
[PubMed:17322186] [WorldCat.org] [DOI] (P p)

Y Quentin, G Fichant, F Denizot
Inventory, assembly and analysis of Bacillus subtilis ABC transport systems.
J Mol Biol: 1999, 287(3);467-84
[PubMed:10092453] [WorldCat.org] [DOI] (P p)

J Cheng, A A Guffanti, T A Krulwich
A two-gene ABC-type transport system that extrudes Na+ in Bacillus subtilis is induced by ethanol or protonophore.
Mol Microbiol: 1997, 23(6);1107-20
[PubMed:9106203] [WorldCat.org] [DOI] (P p)