NatA

Gene name	natA
Synonyms
Essential	no
Product	Na+ ABC transporter (export) (ATP-binding protein)
Function	sodium export
Gene expression levels in SubtiExpress: natA
Interactions involving this protein in SubtInteract: NatA
MW, pI	27 kDa, 8.799
Gene length, protein length	738 bp, 246 aa
Immediate neighbours	natR, natB
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

ABC transporters, metal ion homeostasis (K, Na, Ca, Mg), membrane proteins

This gene is a member of the following regulons

NatR regulon

The gene

Basic information

• Locus tag: BSU02750

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: ABC transporter domain (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • NatA-NatB PubMed

• Localization: membrane associated (via NatB) PubMed

Database entries

• Structure:

• UniProt: P46903

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon: natA-natB PubMed

• Expression browser: natA PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism: NatR: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Mitsuo Ogura, Kensuke Tsukahara, Kentaro Hayashi, Teruo Tanaka
The Bacillus subtilis NatK-NatR two-component system regulates expression of the natAB operon encoding an ABC transporter for sodium ion extrusion.
Microbiology (Reading): 2007, 153(Pt 3);667-675
[PubMed:17322186] [WorldCat.org] [DOI] (P p)

Y Quentin, G Fichant, F Denizot
Inventory, assembly and analysis of Bacillus subtilis ABC transport systems.
J Mol Biol: 1999, 287(3);467-84
[PubMed:10092453] [WorldCat.org] [DOI] (P p)

J Cheng, A A Guffanti, T A Krulwich
A two-gene ABC-type transport system that extrudes Na+ in Bacillus subtilis is induced by ethanol or protonophore.
Mol Microbiol: 1997, 23(6);1107-20
[PubMed:9106203] [WorldCat.org] [DOI] (P p)