Difference between revisions of "NadR"

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=Expression and regulation=
 
=Expression and regulation=
 +
* '''Operon:''' ''[[nifS]]-[[nadR]]'' {{PubMed|8444804}}
  
* '''Operon:'''
+
* '''[[Sigma factor]]:''' [[SigA]] {{PubMed|8444804}}
 
 
* '''Sigma factor:'''  
 
  
 
* '''Regulation:'''  
 
* '''Regulation:'''  
** repressed in the presence of nicotinic acid ([[NadR]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/16199587 PubMed]
+
** repressed in the presence of nicotinic acid ([[NadR]]) {{PubMed|8444804,16199587}} 
  
 
* '''Regulatory mechanism:'''  
 
* '''Regulatory mechanism:'''  
** [[NadR]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/16199587 PubMed]
+
** [[NadR]]: transcription repression {{PubMed|8444804,16199587}}
 
 
 
* '''Additional information:'''  
 
* '''Additional information:'''  
  
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=References=
 
=References=
  
<pubmed>18276644,16199587,,16199587, </pubmed>
+
<pubmed>18276644,8444804,16199587, </pubmed>
  
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 20:24, 26 November 2009

  • Description: transcriptional repressor of genes involved in NAD biosynthesis

Gene name nadR
Synonyms yrxA
Essential no
Product transcriptional repressor
Function regulation of NAD biosynthesis
MW, pI 19 kDa, 5.759
Gene length, protein length 534 bp, 178 aa
Immediate neighbours nifS, pheA
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YrxA context.gif
This image was kindly provided by SubtiList



The gene

Basic information

  • Locus tag: BSU27890

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • repressed in the presence of nicotinic acid (NadR) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Alessandra Albertini, University of Pavia, Italy homepage

Your additional remarks

References

Dmitry A Rodionov, Xiaoqing Li, Irina A Rodionova, Chen Yang, Leonardo Sorci, Etienne Dervyn, Dariusz Martynowski, Hong Zhang, Mikhail S Gelfand, Andrei L Osterman
Transcriptional regulation of NAD metabolism in bacteria: genomic reconstruction of NiaR (YrxA) regulon.
Nucleic Acids Res: 2008, 36(6);2032-46
[PubMed:18276644] [WorldCat.org] [DOI] (I p)

Paola Rossolillo, Ilaria Marinoni, Elisa Galli, Anna Colosimo, Alessandra M Albertini
YrxA is the transcriptional regulator that represses de novo NAD biosynthesis in Bacillus subtilis.
J Bacteriol: 2005, 187(20);7155-60
[PubMed:16199587] [WorldCat.org] [DOI] (P p)

D Sun, P Setlow
Cloning, nucleotide sequence, and regulation of the Bacillus subtilis nadB gene and a nifS-like gene, both of which are essential for NAD biosynthesis.
J Bacteriol: 1993, 175(5);1423-32
[PubMed:8444804] [WorldCat.org] [DOI] (P p)